EasyCompare

Relative Intelligence · Biotechnology

How Revolution Medicines (RVMD) compares with the whole market and its popular alternatives

Built by QuantCommons' quantitative engine, this page is about relative opportunity, not data on RVMD alone. It places RVMD (Revolution Medicines, Inc.) against 18 popular alternatives, its neighboring categories and the entire market of over 10,000 U.S.-listed stocks and ETFs, and surfaces what has done better on consistent outperformance, return for the risk taken, behavior in real market crashes and diversification. The result is a clearer view of where RVMD stands in the market, and of the alternatives worth a closer look.

Period covered: RVMD's full trading record, from February 2020 through September 2026. The crash tests reach back to 2000 using older funds and the S&P 500. All returns include reinvested dividends. Data as of October 20, 2026.

Data as of October 20, 2026. Full tables and charts read best on a larger screen.

Rank the market against RVMD →Chart RVMD vs. 18 alternatives →
On this page12 sections

Key findings

How much would $10,000 in RVMD have grown?

This chart tracks a hypothetical $10,000 investment in RVMD over the past 6 years, with dividends reinvested, alongside the same amount in the S&P 500, investments that ended ahead of RVMD over the same span and RVMD's popular alternatives, among those that traded for the entire period. It shows not only where each investment ended up but also how smooth or uneven the path was.

Note: RVMD began trading on February 13, 2020, so the chart cannot reach back to the dot-com bust, the 2008 financial crisis or five other sell-offs. It covers the most recent 6 years of RVMD's record, starting at the end of September 2020.

From the end of September 2020 to the end of September 2026. The scale is logarithmic, so equal steps up the chart are equal percentage gains. Hover over a fund in the key to pick out its line. 252 of the 3,321 stocks and funds worth at least $500 million that traded the whole period ended ahead of RVMD; the chart shows 5, closest alternatives first. The other 3 lines are popular alternatives, shown for context.

$1,000$10,000$100,0002020202120222023202420252026$1,000$10,000$100,0002020202220242026
  • FIX$329,952+3,200% total · +79.1% a year
  • MU$232,577+2,226% total · +69.0% a year
  • DELL$172,682+1,627% total · +60.8% a year
  • INSW$137,500+1,275% total · +54.8% a year
  • KRYS$77,248+672% total · +40.6% a year
  • RVMD$58,983+490% total · +34.4% a year
  • KYMR$34,599+246% total · +23.0% a year
  • SPY (S&P 500)$24,691+147% total · +16.3% a year
  • ILMN$9,111−8.9% total · −1.5% a year
  • IOVA$4,502−55.0% total · −12.5% a year
Change the dates or add tickers to this chart in EasyCompare

RVMD at a glance

This section summarizes the key facts about the stock, its returns over periods from one to ten years and the risk it has carried, with dividends reinvested throughout. These figures serve as the baseline for every comparison that follows.

Note: RVMD began trading on February 13, 2020, so every figure here, including its worst decline, covers only the time since then. None of them reflect the dot-com bust, the 2008 financial crisis or five other sell-offs.

The company

Market value
$42B
Industry
Biotechnology
Price history from
February 2020

Returns

Past 1 year
+264%total return
Past 3 years
+603%+91.5% a year
Past 5 years
+630%+48.8% a year
Best calendar year
+82.1%2025
Worst calendar year
−36.4%2021
Losing years
2 of 5full calendar years

Risk

Volatility
62.1%typical yearly swing, 5 years
Sharpe ratio
0.95return per unit of risk, 5 years
Worst decline ever
−73.3%Feb 2021 to May 2022
From its all-time high
−11.1%below the peak

RVMD against the whole market

Where RVMD ranks among every stock and fund, and what across the market has done better.

How does RVMD rank among all stocks?

This section ranks RVMD on return, volatility, risk-adjusted return and worst decline against every stock worth at least $300 million with enough history. Where the comparisons with its popular alternatives show how RVMD stacks up against its peers, these rankings show where it stands in the market as a whole.

Ranked against U.S.-listed stocks worth at least $300M that have enough history for each measure, so the count changes from row to row; smaller stocks are left out. Lower volatility and smaller declines rank higher.

MeasureRVMDRankStanding
1-year return+264%21 of 3,287top 1%
3-year return+603%77 of 3,017top 3%
5-year return+630%49 of 2,893top 2%
Volatility, 5 years62.1%2,348 of 2,893bottom 20%
Sharpe ratio, 5 years0.95131 of 2,893top 5%

What has beaten RVMD on both return and risk?

Each dot is an investment, placed by how much it earned a year over the past 5 years (higher is better) and how much its price swung, its volatility (further left is calmer). RVMD sits where the dashed lines cross. Anything in the green box above and to the left earned more than RVMD with smaller swings, a better trade-off over this period on both counts. Past results are no promise, but a name in the box is worth a closer look.

Annual return is the annualized total return with dividends reinvested, and volatility the annualized swing in daily prices, both over 5 years. Labeled dots are the strongest picks from the table below and the names called out above, colored by how close they sit to RVMD; faint dots are 21 more of the 27 in the green region (the strongest, one per fund family). 3,633 stocks and funds worth at least $500 million were screened. Hover over a dot for its figures.

10.0%20.0%30.0%40.0%50.0%60.0%70.0%10.0%20.0%30.0%40.0%50.0%60.0%70.0%80.0%90.0%Volatility over 5 years (annualized)Annual return over 5 yearsMore return, less volatility than RVMDNVDA: +58.0% a year, volatility 51.9%FRO: +52.6% a year, volatility 49.7%AGX: +53.5% a year, volatility 54.1%TRMD: +54.3% a year, volatility 45.9%TNK: +50.5% a year, volatility 45.1%STX: +57.4% a year, volatility 48.7%VST: +53.4% a year, volatility 48.6%IESC: +58.5% a year, volatility 58.0%MPC: +51.2% a year, volatility 33.4%PBR-A: +51.8% a year, volatility 37.5%LPG: +54.6% a year, volatility 43.6%ATI: +61.8% a year, volatility 42.9%CRS: +63.9% a year, volatility 46.5%PBR: +50.3% a year, volatility 37.5%WDC: +53.7% a year, volatility 53.5%FTI: +54.1% a year, volatility 41.3%YPF: +60.7% a year, volatility 54.1%FTAI: +52.1% a year, volatility 57.2%VIST: +59.1% a year, volatility 50.7%BWLP: +60.3% a year, volatility 50.9%CECO: +52.5% a year, volatility 53.9%RVMD: +48.8% a year, volatility 62.1%SPY (S&P 500): +12.7% a year, volatility 17.1%KNSA: +50.2% a year, volatility 53.7%MU: +68.1% a year, volatility 57.1%DELL: +55.2% a year, volatility 54.4%FIX: +77.0% a year, volatility 46.7%INSW: +56.5% a year, volatility 40.5%ANET: +49.0% a year, volatility 49.0%STRL: +78.4% a year, volatility 60.0%BELFB: +78.0% a year, volatility 52.1%RVMDSPY (S&P 500)KNSAMUDELLFIXINSWANETSTRLBELFB10.0%20.0%30.0%40.0%50.0%60.0%70.0%0.0%20.0%40.0%60.0%80.0%100%Volatility over 5 years (annualized)Annual return over 5 yearsMore return, less volatility than RVMDNVDA: +58.0% a year, volatility 51.9%FRO: +52.6% a year, volatility 49.7%AGX: +53.5% a year, volatility 54.1%TRMD: +54.3% a year, volatility 45.9%TNK: +50.5% a year, volatility 45.1%STX: +57.4% a year, volatility 48.7%VST: +53.4% a year, volatility 48.6%IESC: +58.5% a year, volatility 58.0%MPC: +51.2% a year, volatility 33.4%PBR-A: +51.8% a year, volatility 37.5%LPG: +54.6% a year, volatility 43.6%ATI: +61.8% a year, volatility 42.9%CRS: +63.9% a year, volatility 46.5%PBR: +50.3% a year, volatility 37.5%WDC: +53.7% a year, volatility 53.5%FTI: +54.1% a year, volatility 41.3%YPF: +60.7% a year, volatility 54.1%FTAI: +52.1% a year, volatility 57.2%VIST: +59.1% a year, volatility 50.7%BWLP: +60.3% a year, volatility 50.9%CECO: +52.5% a year, volatility 53.9%RVMD: +48.8% a year, volatility 62.1%SPY (S&P 500): +12.7% a year, volatility 17.1%KNSA: +50.2% a year, volatility 53.7%MU: +68.1% a year, volatility 57.1%DELL: +55.2% a year, volatility 54.4%FIX: +77.0% a year, volatility 46.7%INSW: +56.5% a year, volatility 40.5%ANET: +49.0% a year, volatility 49.0%STRL: +78.4% a year, volatility 60.0%BELFB: +78.0% a year, volatility 52.1%RVMDSPY (S&P 500)KNSAMUDELLFIXINSWANETSTRLBELFB
  • Same and neighboring categories, and shared themes
  • The whole market
  • Others in the green region

Is there a better investment than RVMD?

Investments that beat RVMD over the past 5 years on return, volatility, drawdowns, consistency, crash losses or fees, from its popular alternatives out to the whole market.

How this works

The table below lists investments that beat RVMD over the past 5 years on at least one of these measures: a higher annual return with lower volatility, a higher annual return at similar volatility, a similar return with lower volatility, a higher Sharpe ratio with a smaller worst decline, a higher total return in most periods from 3 months to 10 years, or smaller losses in recent market crashes. It checks RVMD's popular alternatives first, then the rest of its own and neighboring categories, then every stock and fund worth at least $500 million, and shows the strongest few in each group. The full list of those with a higher return and lower volatility than RVMD follows the table.

Annual return is the annualized total return with dividends reinvested. Annual return, volatility and the Sharpe ratio cover 5 years; the worst decline covers the past 10 years. Green marks a better figure than RVMD's. "On the frontier" means no other option shown or tested earned more with less volatility. Funds that hold the same thing are shown once. Beyond the popular alternatives, nothing with more than 1.5× RVMD's volatility counts as better.

These figures cover the past 5 years. Green marks a better figure than RVMD's.

Screen the whole market against RVMD for any period in BetterThanSPYOpen these 8 in EasyCompare
InvestmentWhy it is betterPast 5 yearsDownsideLong runFit
Annual return?higher is betterVolatility?lower is calmerSharpe?return per unit of riskWorst decline?past 10 years5Y returntotalCorr. with RVMD?lower diversifies moreExpenseper year
RVMDRevolution Medicines, Inc. · this page
+48.8%62.1%0.95−73.3%+630%1.00—
SPYState Street SPDR S&P 500 ETF · S&P 500
+12.7%17.1%0.79−33.7%+81.7%0.420.09%
Same and neighboring categories, and shared themesbest 1 shownEverything else in Biotechnology and the categories next to it (Pharmaceuticals, Life Sciences Tools, Contract Research), plus RVMD's specific themes. 1 of 86 passed at least one test.
KNSAKiniksa Pharmaceuticals International, plc · Biotechnology
Higher return, lower volatility+50.2%53.7%1.02−83.1%+665%0.31—
The whole marketbest 6 shownEvery other stock and fund worth at least $500 million. 38 of 3,531 passed at least one test.
MUMicron Technology, Inc. · Semiconductors
Higher return, lower volatilityHigher Sharpe, smaller worst declineHigher return in most periods+68.1%57.1%1.20−57.6%+1,244%0.33—
DELLDell Technologies Inc. · Computer Hardware
Higher return, lower volatilityHigher Sharpe, smaller worst declineHigher return in most periods+55.2%54.4%1.08−59.6%+800%0.17—
FIXComfort Systems USA, Inc. · Engineering & Construction
On the frontierHigher return, lower volatilityHigher Sharpe, smaller worst declineSmaller losses in recent crashes+77.0%46.7%1.46−49.7%+1,636%0.39—
INSWInternational Seaways, Inc. · Oil & Gas
On the frontierHigher return, lower volatilityHigher Sharpe, smaller worst declineSmaller losses in recent crashes+56.5%40.5%1.31−57.4%+839%-0.06—
ANETArista Networks, Inc. · Communications Equipment
Similar return, lower volatilityHigher Sharpe, smaller worst declineSmaller losses in recent crashes+49.0%49.0%1.06−52.2%+634%0.30—
STRLSterling Infrastructure, Inc. · Engineering & Construction
Higher return, similar volatilityHigher Sharpe, smaller worst decline+78.4%60.0%1.26−59.6%+1,708%0.32—
What these numbers mean for RVMD
Annual return
RVMD returned 48.8% a year over the past 5 years with dividends reinvested, against 12.7% a year for the S&P 500. At that pace, $10,000 became about $73,000. Annual return is the steady yearly rate that would produce the same total result, so investments held over the same span compare fairly. Guide: What is performance and return? →
Volatility
RVMD's volatility over the past 5 years was 62.1%, 3.6 times the S&P 500's 17.1%. Volatility measures how widely returns swing around their average: in roughly two years out of three, RVMD's return lands within 62.1% of its average, either way. The higher it is, the rougher the ride and the harder it is to hold through a slump. Guide: Understanding and measuring risk (volatility) →
Sharpe ratio
RVMD's Sharpe ratio over the past 5 years was 0.95, against 0.79 for the S&P 500, so RVMD earned more for each unit of risk than an index fund did. The Sharpe ratio is the return earned above cash for each unit of volatility: two investments with the same return are not equal if one got there with far bigger swings. Guide: Balancing reward with risk (Sharpe ratio) →
Worst decline
RVMD's worst fall from a peak to a low over the past 10 years was 73.3%, against 33.7% for the S&P 500. Losses and gains are not symmetric: climbing back from a 73.3% fall takes a 274% gain. Guide: Market crash risk and tail risk →
Correlation
Over the past 5 years, RVMD's monthly returns had a correlation of 0.42 with the S&P 500. Correlation runs from 1 (moving in lockstep) through 0 (unrelated) to −1 (moving in opposite directions). They often move together: some diversification next to an index fund, but not a cushion. In the table, the correlation column measures each option against RVMD instead: the lower it is, the more that option would diversify a RVMD holding. Guide: Correlation and diversification →
Show all 27 stocks and funds worth at least $500 million that earned more than RVMD with less volatility

Out of 3,633 tested over 5 years. Best first; funds that hold the same thing are listed once.

#InvestmentFound inAnnual returnVolatilitySharpeWorst decline5Y returnCorr. with RVMDExpense
1
MUMicron Technology, Inc. · Semiconductors
Whole market+68.1%57.1%1.20−57.6%+1,244%0.33—
2
DELLDell Technologies Inc. · Computer Hardware
Whole market+55.2%54.4%1.08−59.6%+800%0.17—
3
FIXComfort Systems USA, Inc. · Engineering & Construction
Whole market+77.0%46.7%1.46−49.7%+1,636%0.39—
4
INSWInternational Seaways, Inc. · Oil & Gas
Whole market+56.5%40.5%1.31−57.4%+839%-0.06—
5
NVDANVIDIA Corporation · Semiconductors
Whole market+58.0%51.9%1.14−66.3%+884%0.25—
6
FROFrontline Plc · Oil & Gas
Whole market+52.6%49.7%1.10−52.0%+726%-0.06—
7
AGXArgan, Inc. · Engineering & Construction
Whole market+53.5%54.1%1.06−56.7%+751%0.38—
8
TRMDTORM plc · Marine Shipping
Whole market+54.3%45.9%1.18−60.6%+776%-0.04—
9
TNKTeekay Tankers Ltd. · Marine Shipping
Whole market+50.5%45.1%1.14−63.4%+673%-0.16—
10
STXSeagate Technology Holdings plc · Computer Hardware
Whole market+57.4%48.7%1.18−57.0%+866%0.44—
11
VSTVistra Corp. · Independent Power Producers
Whole market+53.4%48.6%1.13−53.3%+748%0.08—
12
IESCIES Holdings, Inc. · Engineering & Construction
Whole market+58.5%58.0%1.09−54.3%+900%0.47—
13
MPCMarathon Petroleum Corporation · Oil & Gas
Whole market+51.2%33.4%1.41−79.7%+690%-0.08—
14
PBR-APetróleo Brasileiro S.A. - Petrobras · Integrated Oil & Gas
Whole market+51.8%37.5%1.31−71.7%+705%-0.03—
15
LPGDorian LPG Ltd. · Oil & Gas Midstream
Whole market+54.6%43.6%1.22−62.9%+783%-0.11—
16
ATIATI Inc. · Metals & Mining
Whole market+61.8%42.9%1.34−82.4%+1,008%0.14—
17
CRSCarpenter Technology Corporation · Metals & Mining
Whole market+63.9%46.5%1.30−74.7%+1,082%0.30—
18
PBRPetróleo Brasileiro S.A. - Petrobras · Integrated Oil & Gas
Whole market+50.3%37.5%1.28−75.3%+667%-0.08—
19
WDCWestern Digital Corporation · Computer Hardware
Whole market+53.7%53.5%1.07−70.5%+759%0.46—
20
BELFBBel Fuse Inc. · Hardware, Equipment & Parts
Whole market+78.0%52.1%1.37−79.8%+1,688%0.28—
21
FTITechnipFMC plc · Oilfield Services
Whole market+54.1%41.3%1.26−85.8%+769%0.20—
22
YPFYPF Sociedad Anónima · Integrated Oil & Gas
Whole market+60.7%54.1%1.14−90.1%+971%0.16—
23
FTAIFTAI Aviation Ltd. · Aerospace & Defense
Whole market+52.1%57.2%1.02−72.8%+713%0.30—
24
VISTVista Energy, S.A.B. de C.V. · Exploration & Production
Whole market+59.1%50.7%1.17−81.2%+920%0.02—
25
BWLPBW LPG Limited · Marine Shipping
Whole market+60.3%50.9%1.19−68.8%+958%0.07—
26
CECOCECO Environmental Corp. · Industrial - Pollution & Treatment Controls
Whole market+52.5%53.9%1.05−74.1%+725%0.21—
27
KNSAKiniksa Pharmaceuticals International, plc · Biotechnology
Same or nearby category+50.2%53.7%1.02−83.1%+665%0.31—

RVMD against its popular alternatives

The investments people most often weigh against RVMD, compared period by period and year by year.

How do RVMD's risk and return compare with its alternatives?

This map plots each investment's annual return over the past 5 years against its volatility, the size of its typical price swings. Investments toward the upper left earned more for a smoother ride, and those toward the lower right earned less for a rougher one. The dashed lines cross at RVMD, which divides the map into what did better or worse on each measure.

Green points earned more than RVMD with less volatility; red points earned less with more. Hover over a point for its figures. Total returns with dividends reinvested, annualized.

10.0%20.0%30.0%40.0%50.0%60.0%70.0%80.0%90.0%100.0%−60.0%−40.0%−20.0%0.0%20.0%40.0%60.0%Volatility over 5 years (annualized)Annual return over 5 yearsHigher return, lower volatilityLower return, higher volatilityRVMD: 48.8% a year, volatility 62.1%SPY (S&P 500): 12.7% a year, volatility 17.1%KYMR: 16.7% a year, volatility 72.3%IOVA: −10.4% a year, volatility 94.4%ERAS: −5.4% a year, volatility 82.8%SDGR: −16.0% a year, volatility 65.7%RXRX: −27.6% a year, volatility 93.6%FATE: −49.0% a year, volatility 93.9%KRYS: 46.1% a year, volatility 76.3%COGT: 29.9% a year, volatility 94.4%KURA: −10.3% a year, volatility 62.7%BEAM: −23.3% a year, volatility 75.0%NTLA: −38.0% a year, volatility 78.0%ARVN: −38.2% a year, volatility 68.6%ILMN: −7.8% a year, volatility 46.9%GILD: 22.8% a year, volatility 24.9%AMGN: 19.6% a year, volatility 24.9%TMO: 2.9% a year, volatility 27.8%MRK: 16.3% a year, volatility 24.8%CRSP: −12.7% a year, volatility 60.9%RVMDSPY (S&P 500)KYMRIOVAERASSDGRRXRXFATEKRYSCOGTKURABEAMNTLAARVNILMNGILDAMGNTMOCRSP0.0%20.0%40.0%60.0%80.0%100%−60.0%−40.0%−20.0%0.0%20.0%40.0%60.0%Volatility over 5 years (annualized)Annual return over 5 yearsHigher return, lower volatilityLower return, higher volatilityRVMD: 48.8% a year, volatility 62.1%SPY (S&P 500): 12.7% a year, volatility 17.1%KYMR: 16.7% a year, volatility 72.3%IOVA: −10.4% a year, volatility 94.4%ERAS: −5.4% a year, volatility 82.8%SDGR: −16.0% a year, volatility 65.7%RXRX: −27.6% a year, volatility 93.6%FATE: −49.0% a year, volatility 93.9%KRYS: 46.1% a year, volatility 76.3%COGT: 29.9% a year, volatility 94.4%KURA: −10.3% a year, volatility 62.7%BEAM: −23.3% a year, volatility 75.0%NTLA: −38.0% a year, volatility 78.0%ARVN: −38.2% a year, volatility 68.6%ILMN: −7.8% a year, volatility 46.9%GILD: 22.8% a year, volatility 24.9%AMGN: 19.6% a year, volatility 24.9%TMO: 2.9% a year, volatility 27.8%MRK: 16.3% a year, volatility 24.8%CRSP: −12.7% a year, volatility 60.9%RVMDSPY (S&P 500)KYMRIOVAERASSDGRRXRXFATEKRYSCOGTKURABEAMNTLAARVNILMNGILDAMGNTMO
All figures
InvestmentAnnual returnVolatility
RVMD This pageRevolution Medicines, Inc.+48.8%62.1%
KRYS Krystal Biotech, Inc.+46.1%76.3%
COGT Cogent Biosciences, Inc.+29.9%94.4%
GILD Gilead Sciences, Inc.+22.8%24.9%
AMGN Amgen Inc.+19.6%24.9%
KYMR Kymera Therapeutics, Inc.+16.7%72.3%
MRK Merck & Co., Inc.+16.3%24.8%
SPY S&P 500State Street SPDR S&P 500 ETF+12.7%17.1%
TMO Thermo Fisher Scientific Inc.+2.9%27.8%
ERAS Erasca, Inc.−5.4%82.8%
ILMN Illumina, Inc.−7.8%46.9%
KURA Kura Oncology, Inc.−10.3%62.7%
IOVA Iovance Biotherapeutics, Inc.−10.4%94.4%
CRSP CRISPR Therapeutics AG−12.7%60.9%
SDGR Schrödinger, Inc.−16.0%65.7%
BEAM Beam Therapeutics Inc.−23.3%75.0%
RXRX Recursion Pharmaceuticals, Inc.−27.6%93.6%
NTLA Intellia Therapeutics, Inc.−38.0%78.0%
ARVN Arvinas, Inc.−38.2%68.6%
FATE Fate Therapeutics, Inc.−49.0%93.9%
Open these 20 in EasyCompare

Has RVMD consistently beaten its popular alternatives?

This section compares RVMD with the investments people most often weigh against it, checking each one over seven periods from one month to five years. Counting how often an alternative earned more than RVMD helps separate lasting outperformance from a single strong stretch.

A green cell means the alternative earned more than RVMD over that period. "Qualified" marks those that did so in at least 3 of 5 short-term periods and 2 of 2 long-term periods.

InvestmentPeriods outperformed Short termLong termRisk · 5 yearsFund
1M3M6MYTD1Y3Y5YVolatilitylower is calmerSharpehigher is betterWorst declinepast 10 yearsExpenseAssetsOverlapsame sectors
RVMD Revolution Medicines, Inc. (this page)—+2.0%+9.0%+34.4%+149%+264%+603%+630%62.1%0.95−73.3%—$42B—
KYMR BiotechnologyKymera Therapeutics, Inc.0/5 short1/2 long−3.6%+2.2%+30.5%+55.9%+87.5%+834%+116%72.3%0.56−87.5%—$9.3B—
IOVA BiotechnologyIovance Biotherapeutics, Inc.5/5 short0/2 long+45.8%+196%+293%+490%+541%+346%−42.4%94.4%0.36−96.8%—$6.7B—
ILMN Medical - Diagnostics & ResearchIllumina, Inc.3/5 short0/2 long+12.2%+45.1%+102%+99.4%+169%+130%−33.3%46.9%0.06−86.2%—$40B—
GILD Drug Manufacturers - GeneralGilead Sciences, Inc.2/5 short0/2 long+4.0%+18.2%+16.6%+31.0%+30.3%+121%+180%24.9%0.95−30.5%—$194B—
AMGN Drug Manufacturers - GeneralAmgen Inc.2/5 short0/2 long+11.6%+21.2%+27.0%+36.7%+48.7%+72.2%+145%24.9%0.85−24.9%—$237B—
TMO Medical - Diagnostics & ResearchThermo Fisher Scientific Inc.2/5 short0/2 long+4.3%+30.7%+30.9%+16.3%+26.8%+49.5%+15.1%27.8%0.24−40.9%—$254B—
ERAS BiotechnologyErasca, Inc.2/5 short0/2 long−2.8%−22.3%−32.7%+307%+494%+559%−24.1%82.8%0.35−95.7%—$5.1B—
SDGR Software - ApplicationSchrödinger, Inc.2/5 short0/2 long−22.6%+56.0%+82.8%+30.1%+6.5%+6.5%−58.2%65.7%0.06−90.2%—$1.8B—
MRK Drug Manufacturers - GeneralMerck & Co., Inc.1/5 short0/2 long−0.8%+19.9%+28.3%+42.2%+76.8%+58.3%+113%24.8%0.74−43.4%—$366B—
RXRX BiotechnologyRecursion Pharmaceuticals, Inc.1/5 short0/2 long−7.8%+26.6%−0.8%−12.9%−45.2%−38.7%−80.2%93.6%0.10−93.1%—$2.0B—
FATE BiotechnologyFate Therapeutics, Inc.1/5 short0/2 long−18.6%−26.4%+48.2%+109%+33.8%+3.0%−96.5%93.9%-0.23−99.4%—$240M—
KRYS BiotechnologyKrystal Biotech, Inc.0/5 short0/2 long−2.5%−4.1%+17.7%+31.8%+66.1%+199%+565%76.3%0.79−53.4%—$9.6B—
COGT BiotechnologyCogent Biosciences, Inc.0/5 short0/2 long−2.4%−18.4%−15.6%−10.1%+92.6%+254%+269%94.4%0.68−98.1%—$5.4B—
KURA BiotechnologyKura Oncology, Inc.0/5 short0/2 long−14.0%−6.6%+2.0%−3.5%−0.1%+20.7%−42.1%62.7%0.14−86.7%—$888M—
CRSP BiotechnologyCRISPR Therapeutics AG0/5 short0/2 long−14.5%+6.2%−13.5%−7.2%−32.6%+29.2%−49.3%60.9%0.08−85.1%—$4.8B—
BEAM BiotechnologyBeam Therapeutics Inc.0/5 short0/2 long−1.3%−5.3%−20.1%−8.1%−18.6%+40.9%−73.5%75.0%0.01−89.1%—$2.6B—
NTLA BiotechnologyIntellia Therapeutics, Inc.0/5 short0/2 long−3.1%+8.4%−22.2%+28.6%−57.7%−55.6%−90.8%78.0%-0.22−96.5%—$1.7B—
ARVN BiotechnologyArvinas, Inc.0/5 short0/2 long−7.7%−4.5%−29.1%−33.2%−21.2%−48.3%−91.0%68.6%-0.34−94.4%—$494M—
Open these 19 in EasyCompare

How did RVMD do year by year?

This table shows each investment's total return in every full calendar year since 2021, along with where RVMD ranked among its popular alternatives each year. Annual results reveal how consistently each one kept pace with RVMD and how far its good and bad years diverged, detail that multiyear averages tend to smooth over.

Note: RVMD began trading on February 13, 2020, so the table starts with 2021, its first full calendar year, and cannot show how it fared during the dot-com bust, the 2008 financial crisis or five other sell-offs.

Newest year first. Green marks a year in which the fund came out ahead of RVMD; gray means the two finished within a fraction of a point. The rank row places RVMD among the alternatives that traded the full year; dark green is the top quarter and red the bottom quarter.

InvestmentYears ahead of RVMD20252024202320222021
RVMD This pageRevolution Medicines, Inc.—+82.1%+52.5%+20.4%−5.4%−36.4%
Rank among alternativesTop quarter in 2 of 53 of 192 of 196 of 196 of 1913 of 17
SPY S&P 500State Street SPDR S&P 500 ETF2 of 5+17.7%+24.9%+26.2%−18.2%+28.7%
KYMR Kymera Therapeutics, Inc.3 of 5+93.4%+58.0%+2.0%−60.7%+2.4%
IOVA Iovance Biotherapeutics, Inc.1 of 5−63.1%−9.0%+27.2%−66.5%−58.9%
ILMN Illumina, Inc.1 of 5−1.8%−1.3%−31.1%−46.9%+2.8%
GILD Gilead Sciences, Inc.2 of 5+36.6%+18.7%−2.0%+23.6%+29.9%
AMGN Amgen Inc.2 of 5+29.7%−6.8%+13.5%+20.4%+0.9%
TMO Thermo Fisher Scientific Inc.1 of 5+11.8%−1.7%−3.4%−17.3%+43.5%
ERAS Erasca, Inc.0 of 4+48.2%+17.8%−50.6%−72.3%—
SDGR Schrödinger, Inc.1 of 5−7.3%−46.1%+91.5%−46.3%−56.0%
MRK Merck & Co., Inc.2 of 5+9.8%−6.3%+1.0%+49.4%+1.8%
RXRX Recursion Pharmaceuticals, Inc.1 of 4−39.5%−31.4%+27.9%−55.0%—
FATE Fate Therapeutics, Inc.0 of 5−40.5%−55.9%−62.9%−82.8%−35.6%
KRYS Krystal Biotech, Inc.3 of 5+57.4%+26.3%+56.6%+13.3%+16.6%
COGT Cogent Biosciences, Inc.3 of 5+355%+32.6%−49.1%+34.7%−23.6%
KURA Kura Oncology, Inc.0 of 5+19.3%−39.4%+15.9%−11.4%−57.1%
CRSP CRISPR Therapeutics AG1 of 5+33.2%−37.1%+54.0%−46.4%−50.5%
BEAM Beam Therapeutics Inc.1 of 5+11.8%−8.9%−30.4%−50.9%−2.4%
NTLA Intellia Therapeutics, Inc.1 of 5−22.9%−61.8%−12.6%−70.5%+117%
ARVN Arvinas, Inc.1 of 5−38.1%−53.4%+20.3%−58.4%−3.3%
Open these 20 in EasyCompare

Risk and diversification

How RVMD has fallen, how it held up in crashes beside the S&P 500 and its popular alternatives, and what moves independently of it.

What were RVMD's worst declines?

A drawdown is the decline from a peak to the lowest point before a new high. This section presents RVMD's five deepest drawdowns since it began trading in 2020, alongside the S&P 500's return over the same dates, and how long each took to recover. Together, these figures show how much an investor could have lost and how long it took to get back to even.

Note: RVMD began trading on February 13, 2020, so this list cannot include the dot-com bust, the 2008 financial crisis or five other sell-offs. The crash tests on this page show how older funds and the S&P 500 fared through those years.

Green means RVMD fell less than the S&P 500 over the same dates. Based on daily closing prices with dividends reinvested.

DuringRVMD fellS&P 500, same datesPeakLowTime to the lowBack at the peakTime to recover
2022 bear market−73.3%+2.1%Feb 2021May 202215 monthsNov 20242.5 years
No named crash−48.6%−16.6%Nov 2024Apr 20255 monthsNov 20257 months
No named crash−42.5%+4.3%Jun 2020Jul 20201 monthOct 20203 months
Covid crash−42.3%−20.9%Mar 2020Apr 20201 monthMay 20201 month
No named crash−33.6%−6.0%Oct 2020Oct 2020Under a monthFeb 20214 months

How did RVMD do in stock market crashes?

This section measures how far RVMD, the S&P 500 and each alternative fell from peak to trough during every major market crash since 2000. A smaller decline means an investment held up better, and comparing results across crashes shows whether that resilience was consistent or a one-off.

Note: RVMD began trading on February 13, 2020, so its row reads "Not yet trading" for the dot-com bust, the 2008 financial crisis or five other sell-offs. The older alternatives and the S&P 500 show how those crashes played out.

Newest crash first. Each figure is the fund's deepest fall within the crash window; green means a smaller fall than RVMD.

InvestmentHeld up better2023 regional bank crisisMar 20232022 bear marketJan 2022Covid crashFeb 2020Late-2018 sell-offSep 2018February 2018 volatility shockFeb 20182015 China and oil sell-offAug 20152011 euro debt crisisJul 20112010 flash crashMay 20102008 financial crisisOct 2007Dot-com bustMar 2000
RVMD This pageRevolution Medicines, Inc.—−9.5%−46.5%−41.3%Not yet tradingNot yet tradingNot yet tradingNot yet tradingNot yet tradingNot yet tradingNot yet trading
SPY S&P 500State Street SPDR S&P 500 ETF3 of 3−3.4%−24.5%−33.7%−19.3%−6.5%−12.8%−17.9%−1.5%−55.2%−47.5%
KYMR Kymera Therapeutics, Inc.0 of 2−10.7%−77.4%————————
IOVA Iovance Biotherapeutics, Inc.0 of 3−10.5%−65.5%−49.7%−44.6%−4.4%−43.0%−45.3%———
ILMN Illumina, Inc.2 of 3−6.7%−58.2%−31.0%−25.8%−5.3%−36.1%−48.7%−1.9%−57.9%—
GILD Gilead Sciences, Inc.3 of 3−1.6%−20.0%−13.7%−22.7%−5.5%−28.7%−18.2%−2.1%−34.3%−53.6%
AMGN Amgen Inc.3 of 3−1.2%−11.9%−18.3%−14.3%−7.4%−22.1%−12.6%−0.5%−31.3%−60.2%
TMO Thermo Fisher Scientific Inc.3 of 3−2.4%−19.8%−24.8%−17.2%−8.7%−14.7%−24.4%−3.6%−53.9%−41.8%
ERAS Erasca, Inc.0 of 2−9.3%−69.4%————————
SDGR Schrödinger, Inc.2 of 3−7.6%−40.8%−45.4%———————
MRK Merck & Co., Inc.3 of 3−2.4%−10.8%−19.3%−9.7%−6.6%−18.2%−17.4%−2.3%−63.3%−57.5%
RXRX Recursion Pharmaceuticals, Inc.0 of 2−12.7%−72.0%————————
FATE Fate Therapeutics, Inc.0 of 3−13.2%−68.2%−45.8%−32.3%−9.7%−78.3%————
KRYS Krystal Biotech, Inc.2 of 3−5.1%−33.4%−44.1%−24.1%−7.1%—————
COGT Cogent Biosciences, Inc.1 of 3−7.8%−55.7%−59.4%−65.4%——————
KURA Kura Oncology, Inc.2 of 3−3.3%−38.3%−48.8%−39.4%−7.1%—————
CRSP CRISPR Therapeutics AG1 of 3−9.8%−41.0%−42.0%−51.1%−16.3%—————
BEAM Beam Therapeutics Inc.0 of 3−14.0%−61.9%−52.8%———————
NTLA Intellia Therapeutics, Inc.1 of 3−11.0%−66.1%−38.3%−60.4%−9.6%—————
ARVN Arvinas, Inc.1 of 3−10.7%−54.4%−35.3%———————
Open these 20 in EasyCompare

How closely does RVMD move with the S&P 500?

Upside capture measures how much of the S&P 500's gains an investment kept in the months the market rose, and downside capture how much of its losses it took in the months the market fell. An investment that captures more of the gains than the losses has compounded ahead of the market over time. This section compares RVMD with its popular alternatives on both measures, and on beta (how strongly each has moved with the market), over the past 5 years.

Monthly total returns over the past 5 years, measured against SPY. 100% capture or a beta of 1.00 means moving in line with the S&P 500. Green marks a better figure than RVMD's: more upside, less downside or a higher capture ratio. Sorted by capture ratio.

InvestmentUpside captureDownside captureCapture ratioBeta
RVMD This pageRevolution Medicines, Inc.191%89%2.151.39
KRYS Krystal Biotech, Inc.135%11%12.510.49
GILD Gilead Sciences, Inc.73%17%4.430.32
MRK Merck & Co., Inc.73%31%2.320.20
AMGN Amgen Inc.76%34%2.260.41
COGT Cogent Biosciences, Inc.161%120%1.340.31
KYMR Kymera Therapeutics, Inc.153%189%0.811.97
TMO Thermo Fisher Scientific Inc.102%160%0.640.88
ILMN Illumina, Inc.113%242%0.471.42
ERAS Erasca, Inc.67%165%0.410.61
SDGR Schrödinger, Inc.83%215%0.391.62
CRSP CRISPR Therapeutics AG96%253%0.381.75
KURA Kura Oncology, Inc.50%158%0.320.47
BEAM Beam Therapeutics Inc.89%306%0.292.19
IOVA Iovance Biotherapeutics, Inc.27%111%0.240.74
FATE Fate Therapeutics, Inc.74%493%0.152.50
ARVN Arvinas, Inc.46%357%0.131.79
RXRX Recursion Pharmaceuticals, Inc.17%237%0.071.04
NTLA Intellia Therapeutics, Inc.18%318%0.061.79
Open these 19 in EasyCompare

What diversifies RVMD?

Correlation measures how closely two investments move together, on a scale from 1 (in lockstep) through 0 (unrelated) to -1 (in opposite directions). This section lists large ETFs and stocks whose returns have had a low correlation with RVMD's. Because such investments tend not to fall at the same time, pairing RVMD with them can reduce a portfolio's overall swings.

Only ETFs with at least $1.0B in assets and stocks worth at least $10B, with a correlation below 0.5 over the past 5 years and a positive return, are included, ranked by Sharpe ratio; funds that hold the same thing are shown once. The year columns are the years in which RVMD lost money. The last two columns show a portfolio that is 80% RVMD and 20% the other investment, rebalanced monthly.

ETFs

InvestmentCorrelation5Y returnSharpe2022202180/20 mix volatility80/20 mix annual return
RVMD Revolution Medicines, Inc. (this page)1.00+630%0.95−5.4%−36.4%52.3%+49.5%
LVHI InternationalFranklin International Low Volatility High Dividend Index ETF0.17+119%1.48+3.8%+17.8%42.2%+45.1%
DXJ InternationalWisdomTree Japan Hedged Equity Fund0.19+225%1.34+6.0%+18.0%42.4%+47.5%
EMLP Broad MarketFirst Trust North American Energy Infrastructure Fund0.26+101%1.04+10.4%+23.1%42.7%+44.6%
HDV Dividend & IncomeiShares Core High Dividend ETF0.21+83.3%1.00+7.1%+19.6%42.5%+43.9%
SMH TechnologyVanEck Semiconductor ETF0.39+323%0.97−33.5%+42.1%45.0%+49.8%
DBEF InternationalXtrackers MSCI EAFE Hedged Equity ETF0.34+85.0%0.96−5.1%+19.6%42.7%+44.1%
GLD CommoditiesSPDR Gold Shares0.12+126%0.96−0.8%−4.2%42.4%+45.7%
SPMO Broad MarketInvesco S&P 500 Momentum ETF0.38+136%0.93−10.4%+22.7%43.6%+45.9%

Stocks

InvestmentCorrelation5Y returnSharpe2022202180/20 mix volatility80/20 mix annual return
RVMD Revolution Medicines, Inc. (this page)1.00+630%0.95−5.4%−36.4%52.3%+49.5%
CAH Medical - DistributionCardinal Health, Inc.0.08+479%1.55+54.1%−0.4%42.6%+50.5%
CLS Hardware, Equipment & PartsCelestica Inc.0.22+3,143%1.47+1.3%+37.9%45.9%+65.6%
FIX Engineering & ConstructionComfort Systems USA, Inc.0.39+1,636%1.46+17.0%+89.0%46.1%+59.9%
MCK Medical - DistributionMcKesson Corporation0.06+413%1.44+51.8%+44.2%42.5%+49.8%
MPC Oil & Gas Refining & MarketingMarathon Petroleum Corporation-0.08+690%1.41+86.6%+61.0%41.8%+53.7%
Open these 14 in EasyCompare

Common questions

What was RVMD's worst drawdown?

RVMD's deepest decline since it began trading in 2020 was 73.3%, from February 2021 to May 2022. It took about two years from the low to climb back to its old high. Because RVMD launched in February 2020, that record does not include the dot-com bust, the 2008 financial crisis or five other sell-offs.

What were RVMD's best and worst years?

Over five full calendar years, RVMD's best year was 2025, when it returned 82.1%. Its worst was 2021, with a return of -36.4%.

Is there a better investment than RVMD?

Looking beyond its popular alternatives, KNSA (biotechnology) earned more than RVMD with less volatility over the past 5 years: 50.2% a year at 53.7% volatility, against 48.8% a year at 62.1%. Few investments have done better on both counts: only 27 of the 3,633 stocks and funds worth at least $500 million earned more than RVMD with less volatility over the past 5 years, among them NVDA, MU and DELL.

Is RVMD more volatile than the S&P 500?

Yes. RVMD's volatility over the past 5 years was 62.1%, 3.6 times the S&P 500's 17.1%. Volatility measures how widely returns swing around their average: in roughly two years out of three, RVMD's return lands within 62.1% of its average, either way. The higher it is, the rougher the ride and the harder it is to hold through a slump.

What is RVMD's Sharpe ratio?

RVMD's Sharpe ratio over the past 5 years was 0.95, against 0.79 for the S&P 500, so RVMD earned more for each unit of risk than an index fund did. The Sharpe ratio is the return earned above cash for each unit of volatility: two investments with the same return are not equal if one got there with far bigger swings.

How correlated is RVMD with the S&P 500?

Over the past 5 years, RVMD's monthly returns had a correlation of 0.42 with the S&P 500. Correlation runs from 1 (moving in lockstep) through 0 (unrelated) to −1 (moving in opposite directions). They often move together: some diversification next to an index fund, but not a cushion. In the table, the correlation column measures each option against RVMD instead: the lower it is, the more that option would diversify a RVMD holding.

What are the best alternatives to RVMD?

None of the 18 popular alternatives we compared outperformed RVMD in at least 3 of 5 short-term and 2 of 2 long-term timeframes, which says more about RVMD's strength than about its alternatives.

Did RVMD outperform the S&P 500?

RVMD finished ahead of the S&P 500 (SPY) in three of five full calendar years. In 2025, it returned +82.1%, against +17.7% for the index.

How did RVMD do in stock market crashes?

RVMD fell less than the S&P 500 (SPY) in none of the three major crashes it has traded through, and further in three. The clearest case was the 2022 bear market, when RVMD fell 46.5% and the S&P 500 fell 24.5%.

What diversifies RVMD?

These had a low correlation with RVMD over the past 5 years and still earned a positive 5-year return: among large ETFs, LVHI (correlation 0.17), DXJ (correlation 0.19) and EMLP (correlation 0.26); among large stocks, CAH (correlation 0.08), CLS (correlation 0.22) and FIX (correlation 0.39). A correlation near zero means the two have moved largely independently.

How we measure

More research

Popular alternatives to RVMD

Other stocks and ETFs