Relative Intelligence · Biotechnology

How Gilead Sciences (GILD) compares with the whole market and its popular alternatives
Built by QuantCommons' quantitative engine, this page is about relative opportunity, not data on GILD alone. It places GILD (Gilead Sciences, Inc.) against 20+ popular alternatives, its neighboring categories and the entire market of over 10,000 U.S.-listed stocks and ETFs, and surfaces what has done better on consistent outperformance, return for the risk taken, behavior in real market crashes and diversification. The result is a clearer view of where GILD stands in the market, and of the alternatives worth a closer look.
Period covered: GILD's full trading record, from January 1992 through September 2026. All returns include reinvested dividends. Data as of October 20, 2026.
Data as of October 20, 2026. Full tables and charts read best on a larger screen.
On this page12 sections
Key findings
- Right nowGILD has outpaced the market, rising 18.2% over the past 3 months against 3.9% for the S&P 500 and 3.2% for the Nasdaq 100. Its biotechnology peers were far apart over the past 3 months, from PFE (Pfizer, up 23.8%) to JNJ (Johnson & Johnson, up 4.8%). Consistency ↓
- Stock or market?GILD's 18.2% gain over the past 3 months far outran its industry: the biotechnology ETF XBI (State Street SPDR S&P Biotech ETF) rose 1.5%. The S&P 500 rose 3.9%. Its biotechnology peers did not move as one over the past 3 months: PFE (Pfizer) rose 23.8%, while JNJ (Johnson & Johnson) rose 4.8%.
- Past 1 to 3 yearsOver the past year, GILD rose 30.3% against 15.8% for the S&P 500 and 17.9% for the Nasdaq 100. The same gap shows up over 3 years (121% against 89.3%). By year ↓
- Long termGILD turned $10,000 into $30,000 over the past decade, against $42,100 in the S&P 500. That said, the past 5 years have been the better stretch: GILD rose 180% against 81.7% for the S&P 500, after trailing over the decade. Growth of $10,000 ↓
- In a crashThe Covid crash took 13.7% off GILD, against 33.7% for the S&P 500. That was more than REGN (Regeneron Pharmaceuticals, 12.7%) but less than LLY (Eli Lilly and Company, 16.9%). Crash tests ↓
- DiversificationAgainst the S&P 500, GILD has a correlation of 0.21 over 5 years, less closely than 85% of stocks worth at least $300 million. Next to an index fund it is a real diversifier. Over 10 years GILD kept more of the market's gains than of its losses: 52% of the S&P 500's gains in rising months and 36% of its losses in falling ones, with a beta of 0.35. Market capture ↓
- Better options
- Popular alternatives
- ABBV (AbbVie) earned more than GILD with less volatility over the past 5 years: 26.1% a year at 23.4% volatility, against 22.8% a year at 24.9%.
- Whole market
- Few investments have done better on both counts: only three of the 3,633 stocks and funds worth at least $500 million earned more than GILD with less volatility over the past 5 years, among them ABBV (AbbVie), COR (Cencora) and DXJ (WisdomTree Japan Hedged Equity Fund).
How much would $10,000 in GILD have grown?
This chart tracks a hypothetical $10,000 investment in GILD over the past 29 years, with dividends reinvested, alongside the same amount in the S&P 500, investments that ended ahead of GILD over the same span and GILD's popular alternatives, among those that traded for the entire period. A second view covers the past 5 years, the period the better options further down the page are judged on. It shows not only where each investment ended up but also how smooth or uneven the path was.
- $10,000 invested in GILD at the end of September 1997 would have grown to $1,571,438 by September 2026, more than the $132,907 it would have become in SPY, an S&P 500 fund.
- Five of the eight other investments on the chart ended ahead of GILD, and AAPL finished highest, at $20,534,853.
Choose a period
From the end of September 1997 to the end of September 2026. The scale is logarithmic, so equal steps up the chart are equal percentage gains. Hover over a fund in the key to pick out its line. 20 of the 1,042 stocks and funds worth at least $500 million that traded the whole period ended ahead of GILD; the chart shows 5, closest alternatives first. The other 3 lines are popular alternatives, shown for context.
- AAPL$21M+205,249% total · +30.1% a year
- AMZN$11M+114,749% total · +27.5% a year
- APH$3M+29,926% total · +21.7% a year
- SCCO$3M+26,680% total · +21.3% a year
- LRCX$2M+24,786% total · +21.0% a year
- GILD$2M+15,614% total · +19.1% a year
- AMGN$526,909+5,169% total · +14.6% a year
- LLY$396,376+3,864% total · +13.5% a year
- SPY (S&P 500)$132,907+1,229% total · +9.3% a year
- MRK$82,561+726% total · +7.6% a year
From the end of September 2021 to the end of September 2026. The scale is logarithmic, so equal steps up the chart are equal percentage gains. Hover over a fund in the key to pick out its line. 484 of the 3,628 stocks and funds worth at least $500 million that traded the whole period ended ahead of GILD; the chart shows 5, closest alternatives first. The other 3 lines are popular alternatives, shown for context.
- LLY$52,411+424% total · +39.3% a year
- CAH$49,682+397% total · +37.8% a year
- XOM$32,965+230% total · +26.9% a year
- ABBV$29,134+191% total · +23.8% a year
- EXEL$27,629+176% total · +22.5% a year
- GILD$25,496+155% total · +20.6% a year
- AMGN$23,160+132% total · +18.3% a year
- SPY (S&P 500)$19,000+90.0% total · +13.7% a year
- CRL$7,149−28.5% total · −6.5% a year
- ILMN$6,943−30.6% total · −7.0% a year
GILD at a glance
This section summarizes the key facts about the stock, its returns over periods from one to ten years and the risk it has carried, with dividends reinvested throughout. These figures serve as the baseline for every comparison that follows.
- GILD's deepest decline since it began trading in 1992 was 70.8%, from January 1992 to June 1994. It took 14 months from the low to climb back to its old high.
- GILD is trading within 1% of its all-time high.
- Over 29 full calendar years, GILD's best was 2013, when it returned 105%, and its worst was 2016, when it lost 27.6%. It lost money in six of those years.
The company
- Market value
- $194B
- Industry
- Drug Manufacturers - General
- Price history from
- January 1992
Returns
- Past 1 year
- +30.3%total return
- Past 3 years
- +121%+30.3% a year
- Past 5 years
- +180%+22.8% a year
- Past 10 years
- +200%+11.6% a year
- Best calendar year
- +105%2013
- Worst calendar year
- −27.6%2016
- Losing years
- 6 of 29full calendar years
Risk
- Volatility
- 24.9%typical yearly swing, 5 years
- Sharpe ratio
- 0.95return per unit of risk, 5 years
- Worst decline ever
- −70.8%Jan 1992 to Jun 1994
- From its all-time high
- At its highwithin 1%
GILD against the whole market
Where GILD ranks among every stock and fund, and what across the market has done better.
How does GILD rank among all stocks?
This section ranks GILD on return, volatility, risk-adjusted return and worst decline against every stock worth at least $300 million with enough history. Where the comparisons with its popular alternatives show how GILD stacks up against its peers, these rankings show where it stands in the market as a whole.
- GILD's worst decline of the past 10 years ranks in the top 1% of the 2,187 stocks worth at least $300 million, where the top fell the least.
Ranked against U.S.-listed stocks worth at least $300M that have enough history for each measure, so the count changes from row to row; smaller stocks are left out. Lower volatility and smaller declines rank higher.
| Measure | GILD | Rank | Standing |
|---|---|---|---|
| 1-year return | +30.3% | 968 of 3,287 | top 29% |
| 3-year return | +121% | 765 of 3,017 | top 25% |
| 5-year return | +180% | 366 of 2,893 | top 13% |
| 10-year return | +200% | 863 of 2,202 | top 39% |
| Volatility, 5 years | 24.9% | 316 of 2,893 | top 11% |
| Sharpe ratio, 5 years | 0.95 | 128 of 2,893 | top 4% |
| Worst decline, past 10 years | −30.5% | 26 of 2,187 | top 1% |
What has beaten GILD on both return and risk?
Each dot is an investment, placed by how much it earned a year over the past 5 years (higher is better) and how much its price swung, its volatility (further left is calmer). GILD sits where the dashed lines cross. Anything in the green box above and to the left earned more than GILD with smaller swings, a better trade-off over this period on both counts. Past results are no promise, but a name in the box is worth a closer look.
- Two stocks and one ETF worth at least $500 million sit in the green region: each earned more than GILD over the past 5 years with smaller price swings. That is fewer than 1% of the 3,633 screened. Few investments beat it on both counts.
- Among those with at least half GILD's swings, DXJ has the best return for its risk: 26.6% a year at 19.1% volatility, 23% less than GILD's 24.9%, and a Sharpe ratio (return above cash per unit of volatility) of 1.34 against 0.95 for GILD.
- Among GILD's popular alternatives, ABBV is in the region. ABBV earned 26.1% a year against 22.8% a year for GILD, at 23.4% volatility, 6% less than GILD's 24.9%.
Annual return is the annualized total return with dividends reinvested, and volatility the annualized swing in daily prices, both over 5 years. Labeled dots are the strongest picks from the table below and the names called out above, colored by how close they sit to GILD. 3,633 stocks and funds worth at least $500 million were screened. Hover over a dot for its figures.
- Popular alternatives
- The whole market
Is there a better investment than GILD?
Investments that beat GILD over the past 5 years on return, volatility, drawdowns, consistency, crash losses or fees, from its popular alternatives out to the whole market.
- Among GILD's popular alternatives, ABBV earned more than GILD with less volatility over the past 5 years: 26.1% a year at 23.4% volatility, against 22.8% a year at 24.9%.
- Few investments have done better on both counts: only three of the 3,633 stocks and funds worth at least $500 million earned more than GILD with less volatility over the past 5 years, among them ABBV, COR and DXJ.
How this works
The table below lists investments that beat GILD over the past 5 years on at least one of these measures: a higher annual return with lower volatility, a higher annual return at similar volatility, a similar return with lower volatility, a higher Sharpe ratio with a smaller worst decline, a higher total return in most periods from 3 months to 10 years, or smaller losses in recent market crashes. It checks GILD's popular alternatives first, then the rest of its own and neighboring categories, then every stock and fund worth at least $500 million, and shows the strongest few in each group. The full list of those with a higher return and lower volatility than GILD follows the table.
Annual return is the annualized total return with dividends reinvested. Annual return, volatility and the Sharpe ratio cover 5 years; the worst decline covers the past 10 years. Green marks a better figure than GILD's. "On the frontier" means no other option shown or tested earned more with less volatility. Funds that hold the same thing are shown once. Beyond the popular alternatives, nothing with more than 1.5× GILD's volatility counts as better.
These figures cover the past 5 years. Green marks a better figure than GILD's.
| Investment | Why it is better | Past 5 years | Downside | Long run | Fit | ||||
|---|---|---|---|---|---|---|---|---|---|
| Annual return?higher is better | Volatility?lower is calmer | Sharpe?return per unit of risk | Worst decline?past 10 years | 10Y returntotal | Corr. with GILD?lower diversifies more | Expenseper year | |||
| +22.8% | 24.9% | 0.95 | −30.5% | +200% | 1.00 | — | |||
| +12.7% | 17.1% | 0.79 | −33.7% | +321% | 0.21 | 0.09% | |||
| Popular alternativesbest 3 shownThe investments people most often weigh against GILD. 3 of 24 passed at least one test. | |||||||||
| Higher return, lower volatility | +26.1% | 23.4% | 1.11 | −45.1% | +603% | 0.25 | — | ||
| Higher return in most periods | +40.7% | 32.8% | 1.21 | −34.5% | +1,807% | 0.06 | — | ||
EXELExelixis, Inc. · Biotechnology | Higher return in most periods | +24.4% | 35.8% | 0.79 | −57.2% | +448% | 0.04 | — | |
| The whole marketbest 8 shownEvery other stock and fund worth at least $500 million. 53 of 3,536 passed at least one test. | |||||||||
| On the frontierHigher return, similar volatilityHigher return in most periods | +42.1% | 24.7% | 1.55 | −46.1% | +349% | 0.25 | — | ||
| Higher return, similar volatilityHigher return in most periods | +27.1% | 26.5% | 1.04 | −61.0% | +214% | 0.30 | — | ||
| Higher return, similar volatilityHigher return in most periods | +38.7% | 25.0% | 1.44 | −38.1% | +586% | 0.22 | — | ||
| On the frontierHigher return in most periods | +51.2% | 33.4% | 1.41 | −79.7% | +1,387% | 0.21 | — | ||
DXJWisdomTree Japan Hedged Equity Fund · International Equity | On the frontierHigher return, lower volatility | +26.6% | 19.1% | 1.34 | −39.1% | +428% | 0.12 | 0.48% | |
| Higher return, lower volatility | +24.2% | 22.8% | 1.07 | −32.4% | +406% | 0.29 | — | ||
VLUEiShares MSCI USA Value Factor ETF · US Large-Cap Value | On the frontierHigher return in most periods | +15.9% | 18.4% | 0.90 | −39.5% | +286% | 0.35 | 0.15% | |
| On the frontierSimilar return, lower volatility | +23.5% | 18.8% | 1.22 | −75.2% | +350% | 0.31 | — | ||
What these numbers mean for GILD
- Annual return
- GILD returned 22.8% a year over the past 5 years with dividends reinvested, against 12.7% a year for the S&P 500. At that pace, $10,000 became about $28,000. Annual return is the steady yearly rate that would produce the same total result, so investments held over the same span compare fairly. Guide: What is performance and return? →
- Volatility
- GILD's volatility over the past 5 years was 24.9%, 1.5 times the S&P 500's 17.1%. Volatility measures how widely returns swing around their average: in roughly two years out of three, GILD's return lands within 24.9% of its average, either way. The higher it is, the rougher the ride and the harder it is to hold through a slump. Guide: Understanding and measuring risk (volatility) →
- Sharpe ratio
- GILD's Sharpe ratio over the past 5 years was 0.95, against 0.79 for the S&P 500, so GILD earned more for each unit of risk than an index fund did. The Sharpe ratio is the return earned above cash for each unit of volatility: two investments with the same return are not equal if one got there with far bigger swings. Guide: Balancing reward with risk (Sharpe ratio) →
- Worst decline
- GILD's worst fall from a peak to a low over the past 10 years was 30.5%, against 33.7% for the S&P 500. Losses and gains are not symmetric: climbing back from a 30.5% fall takes a 43.8% gain. Guide: Market crash risk and tail risk →
- Correlation
- Over the past 5 years, GILD's monthly returns had a correlation of 0.21 with the S&P 500. Correlation runs from 1 (moving in lockstep) through 0 (unrelated) to −1 (moving in opposite directions). They are only loosely linked, which makes it a real diversifier next to an index fund. In the table, the correlation column measures each option against GILD instead: the lower it is, the more that option would diversify a GILD holding. Guide: Correlation and diversification →
Show all 3 stocks and funds worth at least $500 million that earned more than GILD with less volatility
Out of 3,633 tested over 5 years. Best first; funds that hold the same thing are listed once.
| # | Investment | Found in | Annual return | Volatility | Sharpe | Worst decline | 10Y return | Corr. with GILD | Expense |
|---|---|---|---|---|---|---|---|---|---|
| 1 | DXJWisdomTree Japan Hedged Equity Fund · International Equity | Whole market | +26.6% | 19.1% | 1.34 | −39.1% | +428% | 0.12 | 0.48% |
| 2 | Whole market | +24.2% | 22.8% | 1.07 | −32.4% | +406% | 0.29 | — | |
| 3 | Popular alternative | +26.1% | 23.4% | 1.11 | −45.1% | +603% | 0.25 | — |
GILD against its popular alternatives
The investments people most often weigh against GILD, compared period by period and year by year.
How do GILD's risk and return compare with its alternatives?
This map plots each investment's annual return over the past 5 years against its volatility, the size of its typical price swings. Investments toward the upper left earned more for a smoother ride, and those toward the lower right earned less for a rougher one. The dashed lines cross at GILD, which divides the map into what did better or worse on each measure.
- Only ABBV was both more rewarding and calmer than GILD over the past 5 years, earning a higher annual return with lower volatility.
- 16 of the 24 popular alternatives earned less than GILD over the past 5 years while swinging more, the weaker corner of the map.
- Over the past 5 years, GILD returned 22.8% a year, more than the S&P 500's 12.7%, with higher volatility (24.9% against 17.1%).
Green points earned more than GILD with less volatility; red points earned less with more. Hover over a point for its figures. Total returns with dividends reinvested, annualized.
All figures
| Investment | Annual return | Volatility |
|---|---|---|
| LLY Eli Lilly and Company | +40.7% | 32.8% |
| ABBV AbbVie Inc. | +26.1% | 23.4% |
| EXEL Exelixis, Inc. | +24.4% | 35.8% |
| GILD This pageGilead Sciences, Inc. | +22.8% | 24.9% |
| VRTX Vertex Pharmaceuticals Incorporated | +22.6% | 29.1% |
| AMGN Amgen Inc. | +19.6% | 24.9% |
| NVS Novartis AG | +17.2% | 20.7% |
| MRK Merck & Co., Inc. | +16.3% | 24.8% |
| JNJ Johnson & Johnson | +12.7% | 17.9% |
| SPY S&P 500State Street SPDR S&P 500 ETF | +12.7% | 17.1% |
| INCY Incyte Corporation | +12.2% | 30.1% |
| GSK GSK plc | +9.5% | 24.5% |
| AZN AstraZeneca PLC | +8.7% | 35.7% |
| IONS Ionis Pharmaceuticals, Inc. | +8.3% | 43.9% |
| REGN Regeneron Pharmaceuticals, Inc. | +7.7% | 31.1% |
| NBIX Neurocrine Biosciences, Inc. | +6.6% | 33.2% |
| BMY Bristol-Myers Squibb Company | +5.5% | 24.9% |
| TMO Thermo Fisher Scientific Inc. | +2.9% | 27.8% |
| ALNY Alnylam Pharmaceuticals, Inc. | +2.5% | 50.9% |
| IQV IQVIA Holdings Inc. | +1.3% | 34.7% |
| PFE Pfizer Inc. | −1.7% | 25.4% |
| BIIB Biogen Inc. | −1.8% | 34.7% |
| DHR Danaher Corporation | −3.8% | 29.1% |
| BMRN BioMarin Pharmaceutical Inc. | −5.6% | 33.0% |
| CRL Charles River Laboratories International, Inc. | −5.6% | 43.9% |
| ILMN Illumina, Inc. | −7.8% | 46.9% |
Has GILD consistently beaten its popular alternatives?
This section compares GILD with the investments people most often weigh against it, checking each one over eight periods from one month to ten years. Counting how often an alternative earned more than GILD helps separate lasting outperformance from a single strong stretch.
- EXEL outperformed GILD in every long-term period and in all but one short-term period, the most consistent record in the group.
- Two of the 24 popular alternatives, EXEL and LLY, outperformed GILD in at least 3 of 5 short-term and 2 of 3 long-term timeframes.
A green cell means the alternative earned more than GILD over that period. "Qualified" marks those that did so in at least 3 of 5 short-term periods and 2 of 3 long-term periods.
| Investment | Periods outperformed | Short term | Long term | Risk · 5 years | Fund | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1M | 3M | 6M | YTD | 1Y | 3Y | 5Y | 10Y | Volatilitylower is calmer | Sharpehigher is better | Worst declinepast 10 years | Expense | Assets | Overlapsame sectors | ||
| GILD Gilead Sciences, Inc. (this page) | — | +4.0% | +18.2% | +16.6% | +31.0% | +30.3% | +121% | +180% | +200% | 24.9% | 0.95 | −30.5% | — | $194B | — |
| EXEL QualifiedExelixis, Inc. | 4/5 short3/3 longAll-weather | +12.5% | +16.0% | +47.6% | +47.8% | +86.4% | +205% | +198% | +448% | 35.8% | 0.79 | −57.2% | — | $16B | — |
| LLY QualifiedEli Lilly and Company | 3/5 short2/3 long | +10.2% | +12.1% | +40.0% | +19.4% | +59.7% | +124% | +451% | +1,807% | 32.8% | 1.21 | −34.5% | — | $1.2T | — |
| ABBV Drug Manufacturers - GeneralAbbVie Inc. | 2/5 short2/3 long | +9.9% | +14.8% | +43.8% | +29.8% | +28.3% | +118% | +218% | +603% | 23.4% | 1.11 | −45.1% | — | $511B | — |
| CRL Medical - Diagnostics & ResearchCharles River Laboratories International, Inc. | 5/5 short1/3 long | +13.1% | +43.6% | +70.0% | +55.8% | +71.3% | +70.1% | −25.1% | +280% | 43.9% | 0.09 | −78.2% | — | $15B | — |
| AMGN Drug Manufacturers - GeneralAmgen Inc. | 5/5 short1/3 long | +11.6% | +21.2% | +27.0% | +36.7% | +48.7% | +72.2% | +145% | +266% | 24.9% | 0.85 | −24.9% | — | $237B | — |
| ILMN Medical - Diagnostics & ResearchIllumina, Inc. | 5/5 short1/3 long | +12.2% | +45.1% | +102% | +99.4% | +169% | +130% | −33.3% | +93.0% | 46.9% | 0.06 | −86.2% | — | $40B | — |
| MRK Drug Manufacturers - GeneralMerck & Co., Inc. | 4/5 short1/3 long | −0.8% | +19.9% | +28.3% | +42.2% | +76.8% | +58.3% | +113% | +241% | 24.8% | 0.74 | −43.4% | — | $366B | — |
| TMO Medical - Diagnostics & ResearchThermo Fisher Scientific Inc. | 2/5 short1/3 long | +4.3% | +30.7% | +30.9% | +16.3% | +26.8% | +49.5% | +15.1% | +366% | 27.8% | 0.24 | −40.9% | — | $254B | — |
| IQV Medical - Diagnostics & ResearchIQVIA Holdings Inc. | 2/5 short1/3 long | −0.8% | +31.4% | +51.5% | +18.8% | +26.3% | +45.3% | +6.5% | +260% | 34.7% | 0.21 | −51.5% | — | $44B | — |
| VRTX BiotechnologyVertex Pharmaceuticals Incorporated | 1/5 short1/3 long | +0.8% | +7.1% | +17.2% | +13.8% | +22.8% | +42.2% | +177% | +521% | 29.1% | 0.85 | −41.6% | — | $130B | — |
| NVS Drug Manufacturers - GeneralNovartis AG | 1/5 short1/3 long | +9.0% | +2.7% | +1.8% | +13.1% | +18.8% | +75.9% | +121% | +226% | 20.7% | 0.87 | −26.8% | — | $292B | — |
| ALNY BiotechnologyAlnylam Pharmaceuticals, Inc. | 0/5 short1/3 long | −5.6% | −15.4% | −25.8% | −42.3% | −53.0% | +42.6% | +13.2% | +514% | 50.9% | 0.29 | −58.2% | — | $31B | — |
| AZN Drug Manufacturers - GeneralAstraZeneca PLC | 0/5 short1/3 long | +0.4% | +3.3% | −15.3% | −7.0% | +1.8% | +38.8% | +52.1% | +257% | 35.7% | 0.41 | −28.7% | — | $262B | — |
| DHR Medical - Diagnostics & ResearchDanaher Corporation | 0/5 short1/3 long | +4.0% | +11.6% | +15.0% | −2.2% | +8.3% | +10.8% | −17.6% | +232% | 29.1% | 0.01 | −43.8% | — | $157B | — |
| NBIX BiotechnologyNeurocrine Biosciences, Inc. | 0/5 short1/3 long | −1.4% | −17.9% | +7.9% | +1.0% | +0.5% | +28.6% | +37.4% | +211% | 33.2% | 0.36 | −46.4% | — | $14B | — |
| BIIB Drug Manufacturers - GeneralBiogen Inc. | 5/5 short0/3 long | +11.0% | +21.6% | +32.6% | +36.7% | +65.8% | −5.6% | −8.8% | −18.9% | 34.7% | 0.11 | −72.7% | — | $36B | — |
| REGN BiotechnologyRegeneron Pharmaceuticals, Inc. | 2/5 short0/3 long | +1.2% | +20.3% | +8.0% | +4.4% | +40.7% | +0.8% | +44.9% | +120% | 31.1% | 0.40 | −59.7% | — | $83B | — |
| PFE Drug Manufacturers - GeneralPfizer Inc. | 2/5 short0/3 long | +8.5% | +23.8% | +13.2% | +25.7% | +30.5% | +19.2% | −8.3% | +55.0% | 25.4% | 0.06 | −58.9% | — | $172B | — |
| INCY BiotechnologyIncyte Corporation | 2/5 short0/3 long | −6.4% | +0.8% | +20.3% | +15.0% | +35.3% | +112% | +77.6% | +31.8% | 30.1% | 0.53 | −66.5% | — | $24B | — |
| JNJ Drug Manufacturers - GeneralJohnson & Johnson | 1/5 short0/3 long | −3.8% | +4.8% | +13.6% | +27.1% | +36.9% | +84.6% | +82.1% | +196% | 17.9% | 0.76 | −27.4% | — | $625B | — |
| BMY Drug Manufacturers - GeneralBristol-Myers Squibb Company | 1/5 short0/3 long | −0.5% | +3.6% | +6.6% | +19.1% | +47.8% | +25.8% | +30.6% | +74.8% | 24.9% | 0.34 | −47.7% | — | $126B | — |
| GSK Drug Manufacturers - GeneralGSK plc | 0/5 short0/3 long | −0.9% | +2.1% | −10.1% | +4.7% | +18.9% | +60.0% | +57.2% | +95.1% | 24.5% | 0.49 | −37.6% | — | $102B | — |
| IONS BiotechnologyIonis Pharmaceuticals, Inc. | 0/5 short0/3 long | +1.1% | −14.3% | −39.4% | −43.0% | −38.3% | −1.6% | +48.8% | +58.8% | 43.9% | 0.40 | −70.4% | — | $7.5B | — |
| BMRN BiotechnologyBioMarin Pharmaceutical Inc. | 0/5 short0/3 long | −11.9% | −4.5% | +2.8% | −5.1% | +6.3% | −31.3% | −24.9% | −33.0% | 33.0% | -0.01 | −62.1% | — | $11B | — |
How did GILD do year by year?
This table shows each investment's total return in every full calendar year since 1997, along with where GILD ranked among its popular alternatives each year. Annual results reveal how consistently each one kept pace with GILD and how far its good and bad years diverged, detail that multiyear averages tend to smooth over.
- Ranked against its popular alternatives each year, GILD finished in the top quarter in nine of 29 years and in the bottom quarter in six. In 2025, it ranked 9 of 25.
- GILD finished ahead of the S&P 500 in 19 of its 29 full calendar years.
- Among its popular alternatives, IQV came out ahead of GILD most often, in nine of the 12 years both traded.
Newest year first. Green marks a year in which the fund came out ahead of GILD; gray means the two finished within a fraction of a point. The rank row places GILD among the alternatives that traded the full year; dark green is the top quarter and red the bottom quarter.
| Investment | Years ahead of GILD | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GILD This pageGilead Sciences, Inc. | — | +36.6% | +18.7% | −2.0% | +23.6% | +29.9% | −6.7% | +7.9% | −9.9% | +3.0% | −27.6% | +8.6% | +25.5% | +105% | +79.5% | +12.9% | −16.3% | −15.4% | +11.2% | +41.7% | +23.4% | +50.2% | +20.1% | +71.4% | +3.6% | +58.2% | +53.9% | +31.7% | +6.7% | +53.6% |
| Rank among alternatives | Top quarter in 9 of 29 | 9 of 25 | 5 of 25 | 16 of 25 | 8 of 25 | 10 of 25 | 21 of 25 | 19 of 25 | 21 of 25 | 21 of 25 | 20 of 25 | 12 of 25 | 13 of 25 | 4 of 24 | 4 of 23 | 9 of 23 | 21 of 23 | 21 of 23 | 3 of 23 | 5 of 23 | 10 of 23 | 5 of 23 | 8 of 22 | 2 of 22 | 3 of 22 | 2 of 22 | 6 of 19 | 6 of 18 | 12 of 18 | 6 of 18 |
| SPY S&P 500State Street SPDR S&P 500 ETF | 10 of 29 | +17.7% | +24.9% | +26.2% | −18.2% | +28.7% | +18.3% | +31.2% | −4.6% | +21.7% | +12.0% | +1.2% | +13.5% | +32.3% | +16.0% | +1.9% | +15.1% | +26.4% | −36.8% | +5.1% | +15.9% | +4.8% | +10.7% | +28.2% | −21.6% | −11.7% | −9.8% | +20.4% | +28.7% | +33.5% |
| EXEL Exelixis, Inc. | 9 of 25 | +31.6% | +38.8% | +49.6% | −12.3% | −8.9% | +13.9% | −10.4% | −35.3% | +104% | +164% | +292% | −76.5% | +34.1% | −3.6% | −42.3% | +11.4% | +46.8% | −41.8% | −4.1% | −4.5% | −0.8% | +34.8% | −11.9% | −51.9% | +13.6% | — | — | — | — |
| LLY Eli Lilly and Company | 17 of 29 | +40.3% | +33.3% | +60.9% | +34.3% | +66.1% | +31.0% | +16.2% | +40.5% | +17.8% | −10.4% | +25.4% | +39.8% | +7.3% | +24.2% | +25.2% | +3.6% | −6.2% | −21.3% | +5.7% | −5.2% | +2.6% | −17.6% | +13.1% | −17.6% | −14.4% | +41.9% | −24.3% | +29.1% | +93.6% |
| ABBV AbbVie Inc. | 7 of 13 | +33.1% | +18.9% | −0.2% | +24.0% | +32.4% | +27.7% | +1.5% | −1.0% | +60.1% | +9.8% | −6.5% | +27.9% | +60.7% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| CRL Charles River Laboratories International, Inc. | 13 of 25 | +8.1% | −21.9% | +8.5% | −42.2% | +50.8% | +63.6% | +35.0% | +3.4% | +43.6% | −5.2% | +26.3% | +20.0% | +41.5% | +37.1% | −23.1% | +5.5% | +28.6% | −60.2% | +52.1% | +2.1% | −7.9% | +34.0% | −10.8% | +14.9% | +22.3% | — | — | — | — |
| AMGN Amgen Inc. | 13 of 29 | +29.7% | −6.8% | +13.5% | +20.4% | +0.9% | −2.0% | +27.6% | +15.2% | +22.3% | −7.6% | +4.0% | +42.3% | +34.8% | +36.8% | +18.2% | −3.0% | −2.0% | +24.3% | −32.0% | −13.4% | +22.9% | +3.8% | +27.8% | −14.4% | −11.7% | +6.5% | +130% | +93.3% | −0.4% |
| ILMN Illumina, Inc. | 12 of 25 | −1.8% | −1.3% | −31.1% | −46.9% | +2.8% | +11.5% | +10.6% | +37.3% | +70.7% | −33.3% | +4.0% | +66.9% | +99.0% | +82.4% | −51.9% | +106% | +17.8% | −12.1% | +50.8% | +179% | +48.6% | +34.4% | +109% | −71.3% | −26.9% | — | — | — | — |
| MRK Merck & Co., Inc. | 9 of 29 | +9.8% | −6.3% | +1.0% | +49.4% | +1.8% | −7.2% | +22.3% | +40.0% | −1.5% | +15.0% | −3.9% | +16.9% | +26.9% | +13.1% | +9.6% | +2.9% | +26.7% | −45.3% | +37.3% | +42.8% | +4.0% | −27.7% | −11.2% | −1.2% | −36.0% | +41.8% | −7.7% | +41.6% | +35.7% |
| TMO Thermo Fisher Scientific Inc. | 11 of 29 | +11.8% | −1.7% | −3.4% | −17.3% | +43.5% | +43.7% | +45.6% | +18.2% | +35.0% | −0.1% | +13.8% | +13.1% | +75.8% | +43.2% | −18.8% | +16.1% | +40.0% | −40.9% | +27.4% | +50.3% | −0.2% | +19.8% | +25.3% | −15.7% | +5.6% | +98.2% | −11.4% | −61.5% | +6.7% |
| IQV IQVIA Holdings Inc. | 9 of 12 | +14.7% | −15.1% | +12.9% | −27.4% | +57.5% | +16.0% | +33.0% | +18.7% | +28.7% | +10.8% | +16.6% | +27.0% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| VRTX Vertex Pharmaceuticals Incorporated | 12 of 29 | +12.6% | −1.0% | +40.9% | +31.5% | −7.1% | +7.9% | +32.1% | +10.6% | +103% | −41.4% | +5.9% | +59.9% | +77.3% | +26.2% | −5.2% | −18.3% | +41.0% | +30.8% | −37.9% | +35.2% | +162% | +2.1% | −34.7% | −35.5% | −65.6% | +309% | +17.6% | −9.8% | −18.0% |
| NVS Novartis AG | 10 of 29 | +46.0% | −0.5% | +21.1% | +6.6% | −5.0% | +2.2% | +29.1% | +6.2% | +19.8% | −11.8% | −4.3% | +19.4% | +32.2% | +16.1% | +1.5% | +12.6% | +14.6% | −5.4% | −3.4% | +11.3% | +6.0% | +12.3% | +27.5% | +2.1% | −17.2% | +30.6% | −24.1% | +21.9% | +52.9% |
| ALNY Alnylam Pharmaceuticals, Inc. | 11 of 21 | +69.0% | +22.9% | −19.5% | +40.1% | +30.5% | +12.8% | +58.0% | −42.6% | +239% | −60.2% | −2.9% | +50.8% | +252% | +124% | −17.3% | −44.0% | −28.7% | −15.0% | +35.9% | +60.2% | +78.8% | — | — | — | — | — | — | — | — |
| AZN AstraZeneca PLC | 10 of 29 | +38.0% | −1.2% | +0.8% | +20.4% | +17.9% | +2.9% | +37.4% | +13.9% | +35.3% | −16.7% | +0.1% | +24.6% | +32.0% | +8.6% | +6.0% | +3.5% | +20.4% | +0.3% | −17.1% | +12.7% | +36.9% | −22.0% | +38.2% | −23.2% | −7.9% | +28.7% | −5.3% | +27.0% | +31.8% |
| DHR Danaher Corporation | 14 of 29 | +0.4% | −0.4% | −1.2% | −19.0% | +48.6% | +45.4% | +49.5% | +11.8% | +20.0% | +73.2% | +9.3% | +11.6% | +38.3% | +19.1% | −0.1% | +25.7% | +33.0% | −35.4% | +21.3% | +30.1% | −2.7% | +25.3% | +39.7% | +9.1% | −11.7% | +41.5% | −11.0% | +72.4% | +35.2% |
| NBIX Neurocrine Biosciences, Inc. | 9 of 29 | +3.9% | +3.6% | +10.3% | +40.2% | −11.1% | −10.8% | +50.5% | −8.0% | +100% | −31.6% | +153% | +139% | +24.9% | −12.0% | +11.3% | +181% | −15.0% | −29.5% | −56.4% | −83.4% | +27.2% | −9.6% | +19.4% | −11.0% | +54.9% | +33.9% | +260% | −12.7% | −21.2% |
| BIIB Biogen Inc. | 10 of 29 | +15.1% | −40.9% | −6.6% | +15.4% | −2.0% | −17.5% | −1.4% | −5.5% | +12.3% | −7.4% | −9.8% | +21.4% | +91.0% | +33.0% | +64.1% | +25.3% | +12.3% | −16.3% | +15.7% | +8.6% | −32.0% | +81.5% | +10.6% | −51.9% | +9.1% | +93.0% | +318% | +36.6% | +44.7% |
| REGN Regeneron Pharmaceuticals, Inc. | 13 of 29 | +9.0% | −18.9% | +21.7% | +14.2% | +30.7% | +28.7% | +0.5% | −0.7% | +2.4% | −32.4% | +32.3% | +49.0% | +60.9% | +209% | +68.8% | +35.8% | +31.7% | −24.0% | +20.3% | +26.2% | +72.7% | −37.4% | −20.6% | −34.3% | −20.2% | +177% | +72.8% | −13.8% | −46.9% |
| PFE Pfizer Inc. | 10 of 29 | +0.6% | −2.2% | −41.3% | −10.4% | +66.7% | +3.4% | −6.7% | +25.1% | +16.1% | +4.4% | +7.3% | +5.4% | +26.5% | +20.6% | +28.8% | +0.6% | +8.1% | −16.9% | −8.2% | +15.3% | −10.6% | −22.3% | +17.7% | −22.2% | −12.5% | +43.0% | −21.5% | +68.8% | +82.0% |
| INCY Incyte Corporation | 13 of 29 | +43.0% | +10.0% | −21.8% | +9.4% | −15.6% | −0.4% | +37.3% | −32.9% | −5.5% | −7.5% | +48.3% | +44.4% | +205% | +10.7% | −9.4% | +81.8% | +140% | −62.3% | +72.1% | +9.4% | −46.6% | +46.1% | +50.0% | −76.5% | −21.9% | −17.1% | +60.5% | −16.9% | +74.7% |
| JNJ Johnson & Johnson | 10 of 29 | +47.5% | −4.8% | −8.6% | +6.0% | +11.4% | +10.8% | +16.2% | −5.1% | +24.4% | +15.3% | +1.2% | +17.3% | +34.6% | +10.8% | +9.9% | −0.6% | +11.3% | −7.7% | +3.6% | +12.4% | −3.4% | +25.2% | −2.0% | −7.9% | +14.0% | +14.2% | +12.5% | +29.0% | +34.3% |
| BMY Bristol-Myers Squibb Company | 10 of 29 | +0.1% | +15.8% | −26.1% | +19.0% | +2.9% | +0.4% | +27.7% | −12.9% | +7.7% | −13.5% | +19.3% | +14.2% | +70.0% | −3.8% | +39.4% | +8.8% | +14.8% | −6.1% | +4.8% | +19.9% | −6.2% | −7.2% | +29.1% | −52.4% | −26.2% | +17.1% | −2.8% | +42.9% | +77.1% |
| GSK GSK plc | 10 of 29 | +51.3% | −5.2% | +9.8% | −16.8% | +27.1% | −17.7% | +29.2% | +13.8% | −3.0% | +2.1% | −0.3% | −15.7% | +28.9% | +0.6% | +22.7% | −2.1% | +19.2% | −22.2% | −0.8% | +7.9% | +9.9% | +5.6% | +28.8% | −21.6% | −9.7% | +4.1% | −17.9% | +48.2% | +55.8% |
| IONS Ionis Pharmaceuticals, Inc. | 12 of 29 | +126% | −30.9% | +33.9% | +24.1% | −46.2% | −6.4% | +11.8% | +7.5% | +5.2% | −22.8% | +0.3% | +55.0% | +282% | +44.8% | −28.7% | −8.9% | −21.6% | −10.0% | +41.6% | +112% | −11.2% | −9.2% | −1.4% | −70.3% | +109% | +70.1% | −51.7% | +5.1% | −31.6% |
| BMRN BioMarin Pharmaceutical Inc. | 12 of 26 | −9.6% | −31.8% | −6.8% | +17.1% | +0.8% | +3.7% | −0.7% | −4.5% | +7.6% | −20.9% | +15.9% | +28.5% | +43.0% | +43.1% | +27.7% | +43.2% | +5.7% | −49.7% | +116% | +52.0% | +68.7% | −17.6% | +10.1% | −47.5% | +38.7% | −17.5% | — | — | — |
Risk and diversification
How GILD has fallen, how it held up in crashes beside the S&P 500 and its popular alternatives, and what moves independently of it.
What were GILD's worst declines?
A drawdown is the decline from a peak to the lowest point before a new high. This section presents GILD's five deepest drawdowns since it began trading in 1992, alongside the S&P 500's return over the same dates, and how long each took to recover. Together, these figures show how much an investor could have lost and how long it took to get back to even.
- In all four of GILD's worst declines, the S&P 500 held up better over the same dates.
- Not every decline was the market's doing: GILD fell 60.4% from September 1997 to August 1998, while the S&P 500 rose 3.5%.
- The longest climb back to a previous high took 14 months, after GILD fell 70.8% from January 1992 to June 1994.
Green means GILD fell less than the S&P 500 over the same dates. Based on daily closing prices with dividends reinvested.
| During | GILD fell | S&P 500, same dates | Peak | Low | Time to the low | Back at the peak | Time to recover |
|---|---|---|---|---|---|---|---|
| No named crash | −70.8% | — | Jan 1992 | Jun 1994 | 2.4 years | Aug 1995 | 14 months |
| No named crash | −60.4% | +3.5% | Sep 1997 | Aug 1998 | 11 months | Mar 1999 | 7 months |
| No named crash | −59.8% | +5.1% | Sep 1999 | Dec 1999 | 3 months | Aug 2000 | 8 months |
| No named crash | −58.9% | +2.6% | Jan 1996 | Jul 1996 | 6 months | Sep 1997 | 14 months |
| Dot-com bust | −53.6% | −9.7% | Sep 2000 | Jan 2001 | 4 months | May 2001 | 4 months |
How did GILD do in stock market crashes?
This section measures how far GILD, the S&P 500 and each alternative fell from peak to trough during every major market crash since 2000. A smaller decline means an investment held up better, and comparing results across crashes shows whether that resilience was consistent or a one-off.
- Among its popular alternatives, LLY held up best, falling less than GILD in six of the ten crashes they both traded through.
- GILD fell less than the S&P 500 in five of the ten crashes it has traded through. The clearest case was the 2008 financial crisis, when GILD fell 34.3% and the S&P 500 fell 55.2%.
Newest crash first. Each figure is the fund's deepest fall within the crash window; green means a smaller fall than GILD.
| Investment | Held up better | 2023 regional bank crisisMar 2023 | 2022 bear marketJan 2022 | Covid crashFeb 2020 | Late-2018 sell-offSep 2018 | February 2018 volatility shockFeb 2018 | 2015 China and oil sell-offAug 2015 | 2011 euro debt crisisJul 2011 | 2010 flash crashMay 2010 | 2008 financial crisisOct 2007 | Dot-com bustMar 2000 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| GILD This pageGilead Sciences, Inc. | — | −1.6% | −20.0% | −13.7% | −22.7% | −5.5% | −28.7% | −18.2% | −2.1% | −34.3% | −53.6% |
| SPY S&P 500State Street SPDR S&P 500 ETF | 4 of 10 | −3.4% | −24.5% | −33.7% | −19.3% | −6.5% | −12.8% | −17.9% | −1.5% | −55.2% | −47.5% |
| EXEL Exelixis, Inc. | 1 of 9 | 0.0% | −35.4% | −33.7% | −24.9% | −8.7% | −36.4% | −43.7% | −5.4% | −80.0% | — |
| LLY Eli Lilly and Company | 6 of 10 | −0.6% | −11.7% | −16.9% | −10.2% | −8.6% | −19.6% | −10.9% | 0.0% | −50.0% | −54.3% |
| ABBV AbbVie Inc. | 1 of 6 | −1.5% | −21.9% | −32.1% | −18.1% | −5.8% | −29.8% | — | — | — | — |
| CRL Charles River Laboratories International, Inc. | 2 of 9 | −7.7% | −49.3% | −44.5% | −23.4% | −4.6% | −19.1% | −33.3% | −1.8% | −69.8% | — |
| AMGN Amgen Inc. | 6 of 10 | −1.2% | −11.9% | −18.3% | −14.3% | −7.4% | −22.1% | −12.6% | −0.5% | −31.3% | −60.2% |
| ILMN Illumina, Inc. | 0 of 9 | −6.7% | −58.2% | −31.0% | −25.8% | −5.3% | −36.1% | −48.7% | −1.9% | −57.9% | — |
| MRK Merck & Co., Inc. | 4 of 10 | −2.4% | −10.8% | −19.3% | −9.7% | −6.6% | −18.2% | −17.4% | −2.3% | −63.3% | −57.5% |
| TMO Thermo Fisher Scientific Inc. | 3 of 10 | −2.4% | −19.8% | −24.8% | −17.2% | −8.7% | −14.7% | −24.4% | −3.6% | −53.9% | −41.8% |
| IQV IQVIA Holdings Inc. | 1 of 6 | −6.8% | −35.9% | −48.9% | −19.2% | −5.3% | −28.7% | — | — | — | — |
| VRTX Vertex Pharmaceuticals Incorporated | 3 of 10 | 0.0% | −19.2% | −19.4% | −21.2% | −8.8% | −43.7% | −23.9% | −2.7% | −59.9% | −86.7% |
| NVS Novartis AG | 4 of 10 | −1.1% | −20.4% | −25.5% | −9.9% | −6.6% | −30.1% | −14.5% | −2.6% | −41.7% | −25.7% |
| ALNY Alnylam Pharmaceuticals, Inc. | 1 of 9 | −4.1% | −28.9% | −30.0% | −33.7% | −6.9% | −48.9% | −39.3% | −1.5% | −58.6% | — |
| AZN AstraZeneca PLC | 6 of 10 | −0.5% | −25.7% | −22.6% | −11.4% | −6.4% | −18.0% | −16.4% | −1.1% | −37.4% | −43.5% |
| DHR Danaher Corporation | 4 of 10 | −3.2% | −22.8% | −25.9% | −13.4% | −9.8% | −14.0% | −21.8% | −0.6% | −45.7% | −33.7% |
| NBIX Neurocrine Biosciences, Inc. | 0 of 10 | −3.5% | −24.3% | −27.9% | −45.1% | −5.7% | −44.1% | −32.8% | −7.1% | −83.0% | −65.8% |
| BIIB Biogen Inc. | 3 of 10 | −2.5% | −22.4% | −21.2% | −21.7% | −9.3% | −24.6% | −19.4% | −0.6% | −52.7% | −59.8% |
| REGN Regeneron Pharmaceuticals, Inc. | 3 of 10 | −0.2% | −25.8% | −12.7% | −17.3% | −7.3% | −37.7% | −23.2% | −7.2% | −49.9% | −71.6% |
| PFE Pfizer Inc. | 4 of 10 | −1.8% | −24.6% | −21.8% | −12.3% | −8.1% | −18.2% | −16.1% | −1.8% | −49.8% | −46.0% |
| INCY Incyte Corporation | 2 of 10 | −2.4% | −20.4% | −23.7% | −16.4% | −4.8% | −50.2% | −32.9% | −4.5% | −83.5% | −97.1% |
| JNJ Johnson & Johnson | 6 of 10 | −1.1% | −12.7% | −25.4% | −16.9% | −8.2% | −9.0% | −9.8% | −0.1% | −34.4% | −35.9% |
| BMY Bristol-Myers Squibb Company | 5 of 10 | −2.3% | −16.0% | −29.4% | −22.9% | −4.1% | −16.3% | −10.5% | 0.0% | −39.2% | −69.5% |
| GSK GSK plc | 6 of 10 | −0.3% | −37.6% | −26.5% | −11.5% | −4.3% | −15.7% | −12.4% | −2.0% | −46.6% | −45.1% |
| IONS Ionis Pharmaceuticals, Inc. | 1 of 10 | −5.8% | −26.3% | −32.6% | −18.1% | −8.5% | −48.8% | −25.7% | −2.1% | −45.6% | −74.6% |
| BMRN BioMarin Pharmaceutical Inc. | 0 of 10 | −4.5% | −22.9% | −26.3% | −24.4% | −11.6% | −53.6% | −23.1% | −4.1% | −74.9% | −89.7% |
How closely does GILD move with the S&P 500?
Upside capture measures how much of the S&P 500's gains an investment kept in the months the market rose, and downside capture how much of its losses it took in the months the market fell. An investment that captures more of the gains than the losses has compounded ahead of the market over time. This section compares GILD with its popular alternatives on both measures, and on beta (how strongly each has moved with the market), over the past 10 years.
- Over the past 10 years, GILD captured 52% of the S&P 500's gains in rising months and 36% of its losses in falling months, with a beta of 0.35. That is a defensive profile: it gave up some of the market's upside in exchange for smaller losses.
- LLY took just 6% of the S&P 500's losses, against 36% for GILD, while still keeping 101% of its gains.
- Five of the 24 popular alternatives had a higher capture ratio (upside capture divided by downside capture) than GILD's 1.44, led by LLY, VRTX and EXEL.
Monthly total returns over the past 10 years, measured against SPY. 100% capture or a beta of 1.00 means moving in line with the S&P 500. Green marks a better figure than GILD's: more upside, less downside or a higher capture ratio. Sorted by capture ratio.
| Investment | Upside capture | Downside capture | Capture ratio | Beta |
|---|---|---|---|---|
| GILD This pageGilead Sciences, Inc. | 52% | 36% | 1.44 | 0.35 |
| LLY Eli Lilly and Company | 101% | 6% | 15.73 | 0.37 |
| VRTX Vertex Pharmaceuticals Incorporated | 87% | 50% | 1.75 | 0.46 |
| EXEL Exelixis, Inc. | 74% | 43% | 1.72 | 0.73 |
| ABBV AbbVie Inc. | 92% | 57% | 1.62 | 0.54 |
| AZN AstraZeneca PLC | 60% | 39% | 1.52 | 0.39 |
| MRK Merck & Co., Inc. | 64% | 46% | 1.39 | 0.30 |
| JNJ Johnson & Johnson | 64% | 53% | 1.20 | 0.46 |
| AMGN Amgen Inc. | 74% | 64% | 1.16 | 0.54 |
| NVS Novartis AG | 69% | 64% | 1.08 | 0.49 |
| NBIX Neurocrine Biosciences, Inc. | 69% | 66% | 1.04 | 0.56 |
| DHR Danaher Corporation | 84% | 84% | 1.01 | 0.75 |
| TMO Thermo Fisher Scientific Inc. | 104% | 104% | 1.00 | 0.81 |
| ALNY Alnylam Pharmaceuticals, Inc. | 92% | 93% | 0.99 | 0.73 |
| REGN Regeneron Pharmaceuticals, Inc. | 55% | 66% | 0.84 | 0.19 |
| GSK GSK plc | 51% | 61% | 0.82 | 0.52 |
| CRL Charles River Laboratories International, Inc. | 135% | 175% | 0.77 | 1.30 |
| IQV IQVIA Holdings Inc. | 128% | 167% | 0.77 | 1.31 |
| BMY Bristol-Myers Squibb Company | 55% | 75% | 0.73 | 0.41 |
| PFE Pfizer Inc. | 52% | 81% | 0.65 | 0.54 |
| ILMN Illumina, Inc. | 120% | 200% | 0.60 | 1.19 |
| INCY Incyte Corporation | 52% | 87% | 0.60 | 0.77 |
| IONS Ionis Pharmaceuticals, Inc. | 71% | 125% | 0.56 | 0.74 |
| BIIB Biogen Inc. | 35% | 91% | 0.38 | 0.28 |
| BMRN BioMarin Pharmaceutical Inc. | 20% | 70% | 0.29 | 0.38 |
What diversifies GILD?
Correlation measures how closely two investments move together, on a scale from 1 (in lockstep) through 0 (unrelated) to -1 (in opposite directions). This section lists large ETFs and stocks whose returns have had a low correlation with GILD's. Because such investments tend not to fall at the same time, pairing GILD with them can reduce a portfolio's overall swings.
- Moving a fifth of the money in GILD into DXJ would have cut the portfolio's volatility by 18% over the past 5 years and raised its annual return (+20.6% for GILD alone, +22.4% for the mix).
- FIX made money in six of the six calendar years in which GILD lost money.
- Among large ETFs, LVHI, DXJ and EMLP have moved largely independently of GILD over the past 5 years, with correlations of 0.34 or lower, and each still earned a positive 5-year return.
Only ETFs with at least $1.0B in assets and stocks worth at least $10B, with a correlation below 0.5 over the past 5 years and a positive return, are included, ranked by Sharpe ratio; funds that hold the same thing are shown once. The year columns are the years in which GILD lost money. The last two columns show a portfolio that is 80% GILD and 20% the other investment, rebalanced monthly.
ETFs
| Investment | Correlation | 5Y return | Sharpe | 2023 | 2020 | 2018 | 2016 | 2010 | 2009 | 80/20 mix volatility | 80/20 mix annual return |
|---|---|---|---|---|---|---|---|---|---|---|---|
| GILD Gilead Sciences, Inc. (this page) | 1.00 | +180% | 0.95 | −2.0% | −6.7% | −9.9% | −27.6% | −16.3% | −15.4% | 24.0% | +20.6% |
| LVHI InternationalFranklin International Low Volatility High Dividend Index ETF | 0.34 | +119% | 1.48 | +17.4% | −9.0% | −5.2% | — | — | — | 19.9% | +20.3% |
| DXJ InternationalWisdomTree Japan Hedged Equity Fund | 0.12 | +225% | 1.34 | +42.0% | +3.9% | −19.8% | +1.1% | −1.8% | +2.0% | 19.6% | +22.4% |
| EMLP Broad MarketFirst Trust North American Energy Infrastructure Fund | 0.26 | +101% | 1.04 | +8.0% | −13.4% | −8.7% | +29.8% | — | — | 20.1% | +20.1% |
| SMH TechnologyVanEck Semiconductor ETF | 0.02 | +323% | 0.97 | +73.4% | +55.5% | −9.1% | +35.6% | +19.0% | +60.5% | 20.5% | +25.4% |
| DBEF InternationalXtrackers MSCI EAFE Hedged Equity ETF | 0.28 | +85.0% | 0.96 | +20.1% | +2.1% | −9.5% | +6.3% | — | — | 19.9% | +19.7% |
| GLD CommoditiesSPDR Gold Shares | 0.26 | +126% | 0.96 | +12.7% | +24.8% | −1.9% | +8.0% | +29.3% | +24.0% | 20.4% | +20.7% |
| SPMO Broad MarketInvesco S&P 500 Momentum ETF | 0.14 | +136% | 0.93 | +17.6% | +28.2% | −0.9% | +7.4% | — | — | 20.2% | +21.6% |
| XLE EnergyState Street Energy Select Sector SPDR ETF | 0.33 | +177% | 0.93 | −0.6% | −32.7% | −18.2% | +28.0% | +21.9% | +21.8% | 21.5% | +21.9% |
Stocks
| Investment | Correlation | 5Y return | Sharpe | 2023 | 2020 | 2018 | 2016 | 2010 | 2009 | 80/20 mix volatility | 80/20 mix annual return |
|---|---|---|---|---|---|---|---|---|---|---|---|
| GILD Gilead Sciences, Inc. (this page) | 1.00 | +180% | 0.95 | −2.0% | −6.7% | −9.9% | −27.6% | −16.3% | −15.4% | 24.0% | +20.6% |
| CAH Medical - DistributionCardinal Health, Inc. | 0.25 | +479% | 1.55 | +34.1% | +10.1% | −24.5% | −17.5% | +21.4% | −4.4% | 21.1% | +24.7% |
| CLS Hardware, Equipment & PartsCelestica Inc. | -0.02 | +3,143% | 1.47 | +160% | −2.4% | −16.3% | +7.4% | +2.8% | +105% | 22.3% | +38.8% |
| FIX Engineering & ConstructionComfort Systems USA, Inc. | -0.02 | +1,636% | 1.46 | +79.6% | +6.7% | +0.8% | +18.3% | +8.7% | +17.8% | 21.1% | +34.5% |
| MCK Medical - DistributionMcKesson Corporation | 0.22 | +413% | 1.44 | +24.1% | +27.1% | −28.4% | −28.3% | +13.8% | +62.9% | 20.9% | +24.1% |
| MPC Oil & Gas Refining & MarketingMarathon Petroleum Corporation | 0.21 | +690% | 1.41 | +30.4% | −27.4% | −8.2% | +0.7% | — | — | 21.5% | +26.9% |
Common questions
What was GILD's worst drawdown?
GILD's deepest decline since it began trading in 1992 was 70.8%, from January 1992 to June 1994. It took 14 months from the low to climb back to its old high.
What were GILD's best and worst years?
Over 29 full calendar years, GILD's best year was 2013, when it returned 105%. Its worst was 2016, with a return of -27.6%.
Is there a better investment than GILD?
Among GILD's popular alternatives, ABBV earned more than GILD with less volatility over the past 5 years: 26.1% a year at 23.4% volatility, against 22.8% a year at 24.9%. Few investments have done better on both counts: only three of the 3,633 stocks and funds worth at least $500 million earned more than GILD with less volatility over the past 5 years, among them ABBV, COR and DXJ.
Is GILD more volatile than the S&P 500?
Yes. GILD's volatility over the past 5 years was 24.9%, 1.5 times the S&P 500's 17.1%. Volatility measures how widely returns swing around their average: in roughly two years out of three, GILD's return lands within 24.9% of its average, either way. The higher it is, the rougher the ride and the harder it is to hold through a slump.
What is GILD's Sharpe ratio?
GILD's Sharpe ratio over the past 5 years was 0.95, against 0.79 for the S&P 500, so GILD earned more for each unit of risk than an index fund did. The Sharpe ratio is the return earned above cash for each unit of volatility: two investments with the same return are not equal if one got there with far bigger swings.
How correlated is GILD with the S&P 500?
Over the past 5 years, GILD's monthly returns had a correlation of 0.21 with the S&P 500. Correlation runs from 1 (moving in lockstep) through 0 (unrelated) to −1 (moving in opposite directions). They are only loosely linked, which makes it a real diversifier next to an index fund. In the table, the correlation column measures each option against GILD instead: the lower it is, the more that option would diversify a GILD holding.
What are the best alternatives to GILD?
Of the 24 popular alternatives we compared, two outperformed GILD in at least 3 of 5 short-term and 2 of 3 long-term timeframes, with dividends reinvested: EXEL and LLY.
Did GILD outperform the S&P 500?
GILD finished ahead of the S&P 500 (SPY) in 19 of 29 full calendar years. In 2025, it returned +36.6%, against +17.7% for the index.
How did GILD do in stock market crashes?
GILD fell less than the S&P 500 (SPY) in five of the ten major crashes it has traded through, and further in four. The clearest case was the 2008 financial crisis, when GILD fell 34.3% and the S&P 500 fell 55.2%.
What diversifies GILD?
These had a low correlation with GILD over the past 5 years and still earned a positive 5-year return: among large ETFs, LVHI (correlation 0.34), DXJ (correlation 0.12) and EMLP (correlation 0.26); among large stocks, CAH (correlation 0.25), CLS (correlation -0.02) and FIX (correlation -0.02). A correlation near zero means the two have moved largely independently.
How we measure
- Short-term periods are 1M, 3M, 6M, YTD, 1Y; long-term periods are 3Y, 5Y, 10Y. An investment outperformed in a period when its total return, with dividends reinvested, was higher than GILD's. Returns within 0.5 points or 3% of GILD's, whichever is larger, count as a tie.
- "Qualified" means outperforming in at least 3 of 5 short-term periods and 2 of 3 long-term periods. "All-weather" means outperforming in every long-term period and all but one short-term period.
- Popular alternatives are the funds and stocks most often compared with this one. We include only those that trade today, are not leveraged or inverse, and hold at least $200 million.
- Volatility is the annualized standard deviation of daily returns over 5 years, a measure of how much the price typically swings in a year. The Sharpe ratio is the return above cash for each unit of that volatility.
- A decline, or drawdown, runs from a peak to the lowest close before the next high. The worst decline ever uses all the price history we have; comparisons between funds use the past 10 years so that younger funds are judged on the same stretch.
- Sector overlap is the share of assets two funds hold in the same sectors. Correlation and the mixed-portfolio figures use monthly returns.
- Upside and downside capture follow Morningstar's definition: the compound monthly return in the months the S&P 500 rose (or fell), divided by the S&P 500's compound return in those months. Beta measures how strongly monthly returns have moved with the S&P 500. All three use the same window for every investment.
- Figures are computed from daily adjusted prices and update after each trading day. Past performance does not predict future results.