Relative Intelligence · Pharmaceuticals

How Novartis (NVS) compares with the whole market and its popular alternatives
Built by QuantCommons' quantitative engine, this page is about relative opportunity, not data on NVS alone. It places NVS (Novartis AG) against 20+ popular alternatives, its neighboring categories and the entire market of over 10,000 U.S.-listed stocks and ETFs, and surfaces what has done better on consistent outperformance, return for the risk taken, behavior in real market crashes and diversification. The result is a clearer view of where NVS stands in the market, and of the alternatives worth a closer look.
Period covered: NVS's full trading record, from September 1995 through September 2026. All returns include reinvested dividends. Data as of October 20, 2026.
Data as of October 20, 2026. Full tables and charts read best on a larger screen.
On this page12 sections
Key findings
- Right nowOver the past 6 months, NVS rose 1.8% against 9.1% for the S&P 500 and 11.2% for the Nasdaq 100. Not every peer went the same way. Over the past 6 months, ABBV (AbbVie) rose 43.8% and AZN (AstraZeneca) fell 15.3%. Consistency ↓
- Stock or market?NVS rose 2.7% over the past 3 months, 2.2 points behind the pharmaceuticals ETF IHE (iShares U.S. Pharmaceuticals ETF), which rose 5.0%. The S&P 500 rose 3.9%. Even so, last month cut against the tape: NVS rose 9.0% while the S&P 500 fell 0.6%.
- Past 1 to 3 yearsNVS has outpaced the market, rising 18.8% over the past year against 15.8% for the S&P 500 and 17.9% for the Nasdaq 100. By year ↓
- Long termNVS turned $10,000 into $32,600 over the past decade, against $42,100 in the S&P 500. That said, the past 5 years have been the better stretch: NVS rose 121% against 81.7% for the S&P 500, after trailing over the decade. Growth of $10,000 ↓
- In a crashNVS fell less than the S&P 500 in six of seven sell-offs, but the 2015 China and oil sell-off broke the pattern: it fell 30.1%, more than the S&P 500's 12.8%. Crash tests ↓
- DiversificationAgainst the S&P 500, NVS has a correlation of 0.34 over 5 years, less closely than 63% of stocks worth at least $300 million. Next to an index fund it is some diversification, but not a hedge. Over 10 years, NVS's beta versus the S&P 500 was 0.49: 69% of the S&P 500's gains in rising months and 64% of its losses in falling ones. Market capture ↓
- Better options
- Popular alternatives
- LLY (Eli Lilly and Company), MCK (McKesson) and ABBV (AbbVie) were ahead of NVS in most short and long periods.
- Nearby categories and themes
- CAH (Cardinal Health, health care distribution) and COR (Cencora, health care distribution) were ahead of NVS in most short and long periods.
- Whole market
- Few investments have done better on both counts: only seven of the 3,633 stocks and funds worth at least $500 million earned more than NVS with less volatility over the past 5 years, among them MPLX, DXJ (WisdomTree Japan Hedged Equity Fund) and SDCI (USCF SummerHaven Dynamic Commodity Strategy No K-1 Fund).
How much would $10,000 in NVS have grown?
This chart tracks a hypothetical $10,000 investment in NVS over the past 29 years, with dividends reinvested, alongside the same amount in the S&P 500, investments that ended ahead of NVS over the same span and NVS's popular alternatives, among those that traded for the entire period. A second view covers the past 5 years, the period the better options further down the page are judged on. It shows not only where each investment ended up but also how smooth or uneven the path was.
- $10,000 invested in NVS at the end of September 1997 would have grown to $105,143 by September 2026, less than the $132,907 it would have become in SPY, an S&P 500 fund.
- Six of the eight other investments on the chart ended ahead of NVS, and GILD finished highest, at $1,571,438.
Choose a period
From the end of September 1997 to the end of September 2026. The scale is logarithmic, so equal steps up the chart are equal percentage gains. Hover over a fund in the key to pick out its line. 517 of the 1,042 stocks and funds worth at least $500 million that traded the whole period ended ahead of NVS; the chart shows 5, closest alternatives first. The other 3 lines are popular alternatives, shown for context.
- GILD$2M+15,614% total · +19.1% a year
- AMGN$526,909+5,169% total · +14.6% a year
- LLY$396,376+3,864% total · +13.5% a year
- TMO$235,386+2,254% total · +11.5% a year
- MCK$208,304+1,983% total · +11.0% a year
- JNJ$189,226+1,792% total · +10.7% a year
- SPY (S&P 500)$132,907+1,229% total · +9.3% a year
- NVS$105,143+951% total · +8.5% a year
- MRK$82,561+726% total · +7.6% a year
- TEVA$76,156+662% total · +7.3% a year
From the end of September 2021 to the end of September 2026. Hover over a fund in the key to pick out its line. 709 of the 3,628 stocks and funds worth at least $500 million that traded the whole period ended ahead of NVS; the chart shows 5, closest alternatives first. The other 3 lines are popular alternatives, shown for context.
- LLY$52,411+424% total · +39.3% a year
- MCK$43,941+339% total · +34.5% a year
- TEVA$40,657+307% total · +32.4% a year
- ABBV$29,134+191% total · +23.8% a year
- GILD$25,496+155% total · +20.6% a year
- AMGN$23,160+132% total · +18.3% a year
- NVS$21,146+111% total · +16.2% a year
- SPY (S&P 500)$19,000+90.0% total · +13.7% a year
- TMO$11,986+19.9% total · +3.7% a year
- IQV$11,224+12.2% total · +2.3% a year
NVS at a glance
This section summarizes the key facts about the stock, its returns over periods from one to ten years and the risk it has carried, with dividends reinvested throughout. These figures serve as the baseline for every comparison that follows.
- NVS's deepest decline since it began trading in 1995 was 41.8%, from January 1999 to March 2000. It took about four years from the low to climb back to its old high.
- Over 29 full calendar years, NVS's best was 1997, when it returned 52.9%, and its worst was 1999, when it lost 24.1%. It lost money in eight of those years.
- NVS is 7.1% below its all-time high.
The company
- Market value
- $292B
- Industry
- Drug Manufacturers - General
- Price history from
- September 1995
Returns
- Past 1 year
- +18.8%total return
- Past 3 years
- +75.9%+20.7% a year
- Past 5 years
- +121%+17.1% a year
- Past 10 years
- +226%+12.6% a year
- Best calendar year
- +52.9%1997
- Worst calendar year
- −24.1%1999
- Losing years
- 8 of 29full calendar years
Risk
- Volatility
- 20.7%typical yearly swing, 5 years
- Sharpe ratio
- 0.87return per unit of risk, 5 years
- Worst decline ever
- −41.8%Jan 1999 to Mar 2000
- From its all-time high
- −7.1%below the peak
NVS against the whole market
Where NVS ranks among every stock and fund, and what across the market has done better.
How does NVS rank among all stocks?
This section ranks NVS on return, volatility, risk-adjusted return and worst decline against every stock worth at least $300 million with enough history. Where the comparisons with its popular alternatives show how NVS stacks up against its peers, these rankings show where it stands in the market as a whole.
- NVS's worst decline of the past 10 years ranks in the top 1% of the 2,187 stocks worth at least $300 million, where the top fell the least.
Ranked against U.S.-listed stocks worth at least $300M that have enough history for each measure, so the count changes from row to row; smaller stocks are left out. Lower volatility and smaller declines rank higher.
| Measure | NVS | Rank | Standing |
|---|---|---|---|
| 1-year return | +18.8% | 1,273 of 3,287 | top 39% |
| 3-year return | +75.9% | 1,180 of 3,017 | top 39% |
| 5-year return | +121% | 570 of 2,893 | top 20% |
| 10-year return | +226% | 778 of 2,202 | top 35% |
| Volatility, 5 years | 20.7% | 110 of 2,893 | top 4% |
| Sharpe ratio, 5 years | 0.87 | 200 of 2,893 | top 7% |
| Worst decline, past 10 years | −26.8% | 9 of 2,187 | top 1% |
What has beaten NVS on both return and risk?
Each dot is an investment, placed by how much it earned a year over the past 5 years (higher is better) and how much its price swung, its volatility (further left is calmer). NVS sits where the dashed lines cross. Anything in the green box above and to the left earned more than NVS with smaller swings, a better trade-off over this period on both counts. Past results are no promise, but a name in the box is worth a closer look.
- One stock and six ETFs worth at least $500 million sit in the green region: each earned more than NVS over the past 5 years with smaller price swings. That is fewer than 1% of the 3,633 screened. Few investments beat it on both counts.
- Among those with at least half NVS's swings, DXJ has the best return for its risk: 26.6% a year at 19.1% volatility, 8% less than NVS's 20.7%, and a Sharpe ratio (return above cash per unit of volatility) of 1.34 against 0.87 for NVS.
Annual return is the annualized total return with dividends reinvested, and volatility the annualized swing in daily prices, both over 5 years. Labeled dots are the strongest picks from the table below and the names called out above, colored by how close they sit to NVS. 3,633 stocks and funds worth at least $500 million were screened. Hover over a dot for its figures.
- Popular alternatives
- Same and neighboring categories, and shared themes
- The whole market
- 1 with more than 1.6× NVS's volatility is in the table only
Is there a better investment than NVS?
Investments that beat NVS over the past 5 years on return, volatility, drawdowns, consistency, crash losses or fees, from its popular alternatives out to the whole market.
- Among NVS's popular alternatives, LLY, MCK and ABBV were ahead of NVS in most short and long periods.
- Looking beyond its popular alternatives, CAH (health care distribution) and COR (health care distribution) were ahead of NVS in most short and long periods.
- Few investments have done better on both counts: only seven of the 3,633 stocks and funds worth at least $500 million earned more than NVS with less volatility over the past 5 years, among them MPLX, DXJ and SDCI.
How this works
The table below lists investments that beat NVS over the past 5 years on at least one of these measures: a higher annual return with lower volatility, a higher annual return at similar volatility, a similar return with lower volatility, a higher Sharpe ratio with a smaller worst decline, a higher total return in most periods from 3 months to 10 years, or smaller losses in recent market crashes. It checks NVS's popular alternatives first, then the rest of its own and neighboring categories, then every stock and fund worth at least $500 million, and shows the strongest few in each group. The full list of those with a higher return and lower volatility than NVS follows the table.
Annual return is the annualized total return with dividends reinvested. Annual return, volatility and the Sharpe ratio cover 5 years; the worst decline covers the past 10 years. Green marks a better figure than NVS's. "On the frontier" means no other option shown or tested earned more with less volatility. Funds that hold the same thing are shown once. Beyond the popular alternatives, nothing with more than 1.5× NVS's volatility counts as better.
These figures cover the past 5 years. Green marks a better figure than NVS's.
| Investment | Why it is better | Past 5 years | Downside | Long run | Fit | ||||
|---|---|---|---|---|---|---|---|---|---|
| Annual return?higher is better | Volatility?lower is calmer | Sharpe?return per unit of risk | Worst decline?past 10 years | 10Y returntotal | Corr. with NVS?lower diversifies more | Expenseper year | |||
| +17.1% | 20.7% | 0.87 | −26.8% | +226% | 1.00 | — | |||
| +12.7% | 17.1% | 0.79 | −33.7% | +321% | 0.34 | 0.09% | |||
| Popular alternativesbest 6 shownThe investments people most often weigh against NVS. 6 of 22 passed at least one test. | |||||||||
| Higher return in most periods | +40.7% | 32.8% | 1.21 | −34.5% | +1,807% | 0.30 | — | ||
| Higher return in most periods | +38.7% | 25.0% | 1.44 | −38.1% | +586% | 0.29 | — | ||
| Higher return in most periods | +26.1% | 23.4% | 1.11 | −45.1% | +603% | 0.40 | — | ||
| Higher return in most periods | +22.8% | 24.9% | 0.95 | −30.5% | +200% | 0.27 | — | ||
| Higher return in most periods | +19.6% | 24.9% | 0.85 | −24.9% | +266% | 0.51 | — | ||
| Higher return in most periods | +32.2% | 42.8% | 0.86 | −85.5% | −3.6% | 0.15 | — | ||
| Same and neighboring categories, and shared themesbest 3 shownEverything else in Pharmaceuticals and the categories next to it (Biotechnology, Health Care Distribution, Life Sciences Tools, Medical Devices), plus NVS's specific themes. 3 of 103 passed at least one test. | |||||||||
| On the frontierHigher return in most periods | +42.1% | 24.7% | 1.55 | −46.1% | +349% | 0.34 | — | ||
| Higher return in most periods | +24.2% | 22.8% | 1.07 | −32.4% | +406% | 0.52 | — | ||
| Higher return in most periods | +22.6% | 29.1% | 0.85 | −41.6% | +521% | 0.37 | — | ||
| The whole marketbest 8 shownEvery other stock and fund worth at least $500 million. 177 of 3,508 passed at least one test. | |||||||||
| On the frontierHigher return, lower volatilityHigher return in most periods | +23.5% | 18.8% | 1.22 | −75.2% | +350% | 0.29 | — | ||
DXJWisdomTree Japan Hedged Equity Fund · International Equity | On the frontierHigher return, lower volatilityHigher return in most periods | +26.6% | 19.1% | 1.34 | −39.1% | +428% | 0.35 | 0.48% | |
SDCIUSCF SummerHaven Dynamic Commodity Strategy No K-1 Fund · Bonds | On the frontierHigher return, lower volatilityHigher return in most periods | +20.6% | 18.4% | 1.12 | −45.7% | — | 0.17 | 0.80% | |
DBJPXtrackers MSCI Japan Hedged Equity ETF · International | Higher return, lower volatilityHigher return in most periods | +20.9% | 19.2% | 1.09 | −31.3% | +348% | 0.31 | 0.45% | |
| Higher return, similar volatilityHigher return in most periods | +22.4% | 22.3% | 1.02 | −46.3% | +347% | 0.40 | — | ||
ENFRAlerian Energy Infrastructure ETF · Broad Market | Higher return, lower volatilityHigher return in most periods | +18.4% | 19.1% | 0.98 | −62.6% | +183% | 0.43 | 0.35% | |
| On the frontierHigher return in most periods | +17.3% | 18.2% | 0.97 | −40.0% | +352% | 0.46 | — | ||
LVHIFranklin International Low Volatility High Dividend Index ETF · International Equity | On the frontierSimilar return, lower volatility | +17.0% | 11.1% | 1.48 | −32.4% | +194% | 0.65 | 0.40% | |
What these numbers mean for NVS
- Annual return
- NVS returned 17.1% a year over the past 5 years with dividends reinvested, against 12.7% a year for the S&P 500. At that pace, $10,000 became about $22,100. Annual return is the steady yearly rate that would produce the same total result, so investments held over the same span compare fairly. Guide: What is performance and return? →
- Volatility
- NVS's volatility over the past 5 years was 20.7%, 1.2 times the S&P 500's 17.1%. Volatility measures how widely returns swing around their average: in roughly two years out of three, NVS's return lands within 20.7% of its average, either way. The higher it is, the rougher the ride and the harder it is to hold through a slump. Guide: Understanding and measuring risk (volatility) →
- Sharpe ratio
- NVS's Sharpe ratio over the past 5 years was 0.87, against 0.79 for the S&P 500, so NVS earned more for each unit of risk than an index fund did. The Sharpe ratio is the return earned above cash for each unit of volatility: two investments with the same return are not equal if one got there with far bigger swings. Guide: Balancing reward with risk (Sharpe ratio) →
- Worst decline
- NVS's worst fall from a peak to a low over the past 10 years was 26.8%, against 33.7% for the S&P 500. Losses and gains are not symmetric: climbing back from a 26.8% fall takes a 36.7% gain. Guide: Market crash risk and tail risk →
- Correlation
- Over the past 5 years, NVS's monthly returns had a correlation of 0.34 with the S&P 500. Correlation runs from 1 (moving in lockstep) through 0 (unrelated) to −1 (moving in opposite directions). They are only loosely linked, which makes it a real diversifier next to an index fund. In the table, the correlation column measures each option against NVS instead: the lower it is, the more that option would diversify a NVS holding. Guide: Correlation and diversification →
Show all 7 stocks and funds worth at least $500 million that earned more than NVS with less volatility
Out of 3,633 tested over 5 years. The strongest 5 are listed, best first, with funds that hold the same thing listed once.
| # | Investment | Found in | Annual return | Volatility | Sharpe | Worst decline | 10Y return | Corr. with NVS | Expense |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Whole market | +23.5% | 18.8% | 1.22 | −75.2% | +350% | 0.29 | — | |
| 2 | DXJWisdomTree Japan Hedged Equity Fund · International Equity | Whole market | +26.6% | 19.1% | 1.34 | −39.1% | +428% | 0.35 | 0.48% |
| 3 | SDCIUSCF SummerHaven Dynamic Commodity Strategy No K-1 Fund · Bonds | Whole market | +20.6% | 18.4% | 1.12 | −45.7% | — | 0.17 | 0.80% |
| 4 | DBJPXtrackers MSCI Japan Hedged Equity ETF · International | Whole market | +20.9% | 19.2% | 1.09 | −31.3% | +348% | 0.31 | 0.45% |
| 5 | ENFRAlerian Energy Infrastructure ETF · Broad Market | Whole market | +18.4% | 19.1% | 0.98 | −62.6% | +183% | 0.43 | 0.35% |
NVS against its popular alternatives
The investments people most often weigh against NVS, compared period by period and year by year.
How do NVS's risk and return compare with its alternatives?
This map plots each investment's annual return over the past 5 years against its volatility, the size of its typical price swings. Investments toward the upper left earned more for a smoother ride, and those toward the lower right earned less for a rougher one. The dashed lines cross at NVS, which divides the map into what did better or worse on each measure.
- None of the 22 popular alternatives earned more than NVS over the past 5 years with smaller price swings, so every higher return on the map came with a bumpier ride.
- 14 of the 22 popular alternatives earned less than NVS over the past 5 years while swinging more, the weaker corner of the map.
- Over the past 5 years, NVS returned 17.2% a year, more than the S&P 500's 12.7%, with higher volatility (20.7% against 17.1%).
Green points earned more than NVS with less volatility; red points earned less with more. Hover over a point for its figures. Total returns with dividends reinvested, annualized.
All figures
| Investment | Annual return | Volatility |
|---|---|---|
| LLY Eli Lilly and Company | +40.7% | 32.8% |
| MCK McKesson Corporation | +38.7% | 25.0% |
| TEVA Teva Pharmaceutical Industries Limited | +32.2% | 42.8% |
| ABBV AbbVie Inc. | +26.1% | 23.4% |
| GILD Gilead Sciences, Inc. | +22.8% | 24.9% |
| AMGN Amgen Inc. | +19.6% | 24.9% |
| NVS This pageNovartis AG | +17.2% | 20.7% |
| MRK Merck & Co., Inc. | +16.3% | 24.8% |
| JNJ Johnson & Johnson | +12.7% | 17.9% |
| SPY S&P 500State Street SPDR S&P 500 ETF | +12.7% | 17.1% |
| TAK Takeda Pharmaceutical Company Limited | +11.8% | 19.4% |
| VTRS Viatris Inc. | +10.4% | 33.6% |
| GSK GSK plc | +9.5% | 24.5% |
| AZN AstraZeneca PLC | +8.7% | 35.7% |
| REGN Regeneron Pharmaceuticals, Inc. | +7.7% | 31.1% |
| BMY Bristol-Myers Squibb Company | +5.5% | 24.9% |
| XBI State Street SPDR S&P Biotech ETF | +4.6% | 32.5% |
| TMO Thermo Fisher Scientific Inc. | +2.9% | 27.8% |
| IQV IQVIA Holdings Inc. | +1.3% | 34.7% |
| SNY Sanofi | +0.6% | 25.3% |
| PFE Pfizer Inc. | −1.7% | 25.4% |
| BIIB Biogen Inc. | −1.8% | 34.7% |
| DHR Danaher Corporation | −3.8% | 29.1% |
| NVO Novo Nordisk A/S | −4.0% | 39.1% |
Has NVS consistently beaten its popular alternatives?
This section compares NVS with the investments people most often weigh against it, checking each one over eight periods from one month to ten years. Counting how often an alternative earned more than NVS helps separate lasting outperformance from a single strong stretch.
- Six of the 22 popular alternatives, led by LLY, ABBV and MCK, outperformed NVS in at least 3 of 5 short-term and 2 of 3 long-term timeframes.
- LLY, ABBV and MCK outperformed NVS in every long-term period and in all but one short-term period, the most consistent record in the group.
A green cell means the alternative earned more than NVS over that period. "Qualified" marks those that did so in at least 3 of 5 short-term periods and 2 of 3 long-term periods.
| Investment | Periods outperformed | Short term | Long term | Risk · 5 years | Fund | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1M | 3M | 6M | YTD | 1Y | 3Y | 5Y | 10Y | Volatilitylower is calmer | Sharpehigher is better | Worst declinepast 10 years | Expense | Assets | Overlapsame sectors | ||
| NVS Novartis AG (this page) | — | +9.0% | +2.7% | +1.8% | +13.1% | +18.8% | +75.9% | +121% | +226% | 20.7% | 0.87 | −26.8% | — | $292B | — |
| LLY QualifiedEli Lilly and Company | 5/5 short3/3 longAll-weather | +10.2% | +12.1% | +40.0% | +19.4% | +59.7% | +124% | +451% | +1,807% | 32.8% | 1.21 | −34.5% | — | $1.2T | — |
| ABBV QualifiedAbbVie Inc. | 5/5 short3/3 longAll-weather | +9.9% | +14.8% | +43.8% | +29.8% | +28.3% | +118% | +218% | +603% | 23.4% | 1.11 | −45.1% | — | $511B | — |
| MCK QualifiedMcKesson Corporation | 5/5 short3/3 longAll-weather | +16.2% | +24.0% | +20.2% | +25.5% | +31.3% | +131% | +413% | +586% | 25.0% | 1.44 | −38.1% | — | $120B | — |
| AMGN QualifiedAmgen Inc. | 5/5 short2/3 long | +11.6% | +21.2% | +27.0% | +36.7% | +48.7% | +72.2% | +145% | +266% | 24.9% | 0.85 | −24.9% | — | $237B | — |
| GILD QualifiedGilead Sciences, Inc. | 4/5 short2/3 long | +4.0% | +18.2% | +16.6% | +31.0% | +30.3% | +121% | +180% | +200% | 24.9% | 0.95 | −30.5% | — | $194B | — |
| TEVA QualifiedTeva Pharmaceutical Industries Limited | 4/5 short2/3 long | +2.0% | +31.8% | +27.6% | +32.0% | +110% | +403% | +303% | −3.6% | 42.8% | 0.86 | −85.5% | — | $48B | — |
| TMO Medical - Diagnostics & ResearchThermo Fisher Scientific Inc. | 4/5 short1/3 long | +4.3% | +30.7% | +30.9% | +16.3% | +26.8% | +49.5% | +15.1% | +366% | 27.8% | 0.24 | −40.9% | — | $254B | — |
| IQV Medical - Diagnostics & ResearchIQVIA Holdings Inc. | 4/5 short1/3 long | −0.8% | +31.4% | +51.5% | +18.8% | +26.3% | +45.3% | +6.5% | +260% | 34.7% | 0.21 | −51.5% | — | $44B | — |
| MRK Drug Manufacturers - GeneralMerck & Co., Inc. | 4/5 short1/3 long | −0.8% | +19.9% | +28.3% | +42.2% | +76.8% | +58.3% | +113% | +241% | 24.8% | 0.74 | −43.4% | — | $366B | — |
| JNJ Drug Manufacturers - GeneralJohnson & Johnson | 4/5 short1/3 long | −3.8% | +4.8% | +13.6% | +27.1% | +36.9% | +84.6% | +82.1% | +196% | 17.9% | 0.76 | −27.4% | — | $625B | — |
| VTRS Drug Manufacturers - Specialty & GenericViatris Inc. | 4/5 short1/3 long | +9.1% | +10.6% | +27.3% | +53.1% | +87.1% | +127% | +64.3% | −38.0% | 33.6% | 0.47 | −82.0% | — | $21B | — |
| XBI HealthcareState Street SPDR S&P Biotech ETF | 3/5 short1/3 long | −3.2% | +1.5% | +11.3% | +26.2% | +39.7% | +130% | +25.1% | +159% | 32.5% | 0.30 | −63.9% | 0.35% | $10B | — |
| AZN Drug Manufacturers - GeneralAstraZeneca PLC | 1/5 short1/3 long | +0.4% | +3.3% | −15.3% | −7.0% | +1.8% | +38.8% | +52.1% | +257% | 35.7% | 0.41 | −28.7% | — | $262B | — |
| BIIB Drug Manufacturers - GeneralBiogen Inc. | 5/5 short0/3 long | +11.0% | +21.6% | +32.6% | +36.7% | +65.8% | −5.6% | −8.8% | −18.9% | 34.7% | 0.11 | −72.7% | — | $36B | — |
| BMY Drug Manufacturers - GeneralBristol-Myers Squibb Company | 4/5 short0/3 long | −0.5% | +3.6% | +6.6% | +19.1% | +47.8% | +25.8% | +30.6% | +74.8% | 24.9% | 0.34 | −47.7% | — | $126B | — |
| PFE Drug Manufacturers - GeneralPfizer Inc. | 4/5 short0/3 long | +8.5% | +23.8% | +13.2% | +25.7% | +30.5% | +19.2% | −8.3% | +55.0% | 25.4% | 0.06 | −58.9% | — | $172B | — |
| TAK Drug Manufacturers - Specialty & GenericTakeda Pharmaceutical Company Limited | 4/5 short0/3 long | +8.6% | +20.3% | +16.9% | +33.6% | +48.2% | +56.1% | +75.1% | +30.4% | 19.4% | 0.68 | −54.4% | — | $64B | — |
| REGN BiotechnologyRegeneron Pharmaceuticals, Inc. | 3/5 short0/3 long | +1.2% | +20.3% | +8.0% | +4.4% | +40.7% | +0.8% | +44.9% | +120% | 31.1% | 0.40 | −59.7% | — | $83B | — |
| DHR Medical - Diagnostics & ResearchDanaher Corporation | 2/5 short0/3 long | +4.0% | +11.6% | +15.0% | −2.2% | +8.3% | +10.8% | −17.6% | +232% | 29.1% | 0.01 | −43.8% | — | $157B | — |
| NVO Drug Manufacturers - GeneralNovo Nordisk A/S | 0/5 short0/3 long | −1.1% | −20.0% | −1.5% | −23.9% | −28.5% | −57.0% | −18.5% | +134% | 39.1% | 0.09 | −75.2% | — | $174B | — |
| GSK Drug Manufacturers - GeneralGSK plc | 0/5 short0/3 long | −0.9% | +2.1% | −10.1% | +4.7% | +18.9% | +60.0% | +57.2% | +95.1% | 24.5% | 0.49 | −37.6% | — | $102B | — |
| SNY Drug Manufacturers - GeneralSanofi | 0/5 short0/3 long | −2.6% | −5.9% | −10.3% | −10.7% | −13.4% | −10.0% | +3.0% | +61.5% | 25.3% | 0.15 | −33.5% | — | $99B | — |
How did NVS do year by year?
This table shows each investment's total return in every full calendar year since 1997, along with where NVS ranked among its popular alternatives each year. Annual results reveal how consistently each one kept pace with NVS and how far its good and bad years diverged, detail that multiyear averages tend to smooth over.
- NVS finished ahead of the S&P 500 in ten of its 29 full calendar years.
- Among its popular alternatives, IQV came out ahead of NVS most often, in eight of the 12 years both traded.
- Ranked against its popular alternatives each year, NVS finished in the top quarter in four of 29 years and in the bottom quarter in six. In 2025, it ranked 3 of 23.
Newest year first. Green marks a year in which the fund came out ahead of NVS; gray means the two finished within a fraction of a point. The rank row places NVS among the alternatives that traded the full year; dark green is the top quarter and red the bottom quarter.
| Investment | Years ahead of NVS | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NVS This pageNovartis AG | — | +46.0% | −0.5% | +21.1% | +6.6% | −5.0% | +2.2% | +29.1% | +6.2% | +19.8% | −11.8% | −4.3% | +19.4% | +32.2% | +16.1% | +1.5% | +12.6% | +14.6% | −5.4% | −3.4% | +11.3% | +6.0% | +12.3% | +27.5% | +2.1% | −17.2% | +30.6% | −24.1% | +21.9% | +52.9% |
| Rank among alternatives | Top quarter in 4 of 29 | 3 of 23 | 11 of 23 | 5 of 23 | 14 of 23 | 19 of 23 | 13 of 23 | 7 of 23 | 10 of 23 | 11 of 23 | 13 of 23 | 20 of 23 | 13 of 23 | 13 of 22 | 14 of 21 | 17 of 21 | 10 of 21 | 13 of 21 | 4 of 20 | 16 of 20 | 11 of 19 | 10 of 19 | 7 of 19 | 10 of 19 | 4 of 18 | 15 of 18 | 12 of 18 | 16 of 18 | 13 of 18 | 8 of 18 |
| SPY S&P 500State Street SPDR S&P 500 ETF | 15 of 29 | +17.7% | +24.9% | +26.2% | −18.2% | +28.7% | +18.3% | +31.2% | −4.6% | +21.7% | +12.0% | +1.2% | +13.5% | +32.3% | +16.0% | +1.9% | +15.1% | +26.4% | −36.8% | +5.1% | +15.9% | +4.8% | +10.7% | +28.2% | −21.6% | −11.7% | −9.8% | +20.4% | +28.7% | +33.5% |
| LLY Eli Lilly and Company | 16 of 29 | +40.3% | +33.3% | +60.9% | +34.3% | +66.1% | +31.0% | +16.2% | +40.5% | +17.8% | −10.4% | +25.4% | +39.8% | +7.3% | +24.2% | +25.2% | +3.6% | −6.2% | −21.3% | +5.7% | −5.2% | +2.6% | −17.6% | +13.1% | −17.6% | −14.4% | +41.9% | −24.3% | +29.1% | +93.6% |
| ABBV AbbVie Inc. | 8 of 13 | +33.1% | +18.9% | −0.2% | +24.0% | +32.4% | +27.7% | +1.5% | −1.0% | +60.1% | +9.8% | −6.5% | +27.9% | +60.7% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| MCK McKesson Corporation | 17 of 29 | +44.5% | +23.7% | +24.1% | +51.8% | +44.2% | +27.1% | +26.7% | −28.4% | +12.0% | −28.3% | −4.5% | +29.3% | +67.7% | +25.6% | +11.8% | +13.8% | +62.9% | −40.4% | +29.7% | −1.2% | +64.9% | −1.4% | +19.9% | −27.2% | +4.9% | +61.2% | −71.3% | +46.9% | +96.3% |
| AMGN Amgen Inc. | 15 of 29 | +29.7% | −6.8% | +13.5% | +20.4% | +0.9% | −2.0% | +27.6% | +15.2% | +22.3% | −7.6% | +4.0% | +42.3% | +34.8% | +36.8% | +18.2% | −3.0% | −2.0% | +24.3% | −32.0% | −13.4% | +22.9% | +3.8% | +27.8% | −14.4% | −11.7% | +6.5% | +130% | +93.3% | −0.4% |
| GILD Gilead Sciences, Inc. | 18 of 29 | +36.6% | +18.7% | −2.0% | +23.6% | +29.9% | −6.7% | +7.9% | −9.9% | +3.0% | −27.6% | +8.6% | +25.5% | +105% | +79.5% | +12.9% | −16.3% | −15.4% | +11.2% | +41.7% | +23.4% | +50.2% | +20.1% | +71.4% | +3.6% | +58.2% | +53.9% | +31.7% | +6.7% | +53.6% |
| TEVA Teva Pharmaceutical Industries Limited | 12 of 29 | +41.6% | +111% | +14.5% | +13.9% | −17.0% | −1.5% | −36.4% | −18.6% | −46.0% | −43.2% | +16.7% | +47.4% | +10.9% | −5.1% | −21.0% | −5.9% | +33.6% | −7.4% | +50.9% | −27.1% | +45.2% | +6.1% | +47.8% | +26.1% | −15.5% | +105% | +77.0% | −13.4% | −5.3% |
| TMO Thermo Fisher Scientific Inc. | 17 of 29 | +11.8% | −1.7% | −3.4% | −17.3% | +43.5% | +43.7% | +45.6% | +18.2% | +35.0% | −0.1% | +13.8% | +13.1% | +75.8% | +43.2% | −18.8% | +16.1% | +40.0% | −40.9% | +27.4% | +50.3% | −0.2% | +19.8% | +25.3% | −15.7% | +5.6% | +98.2% | −11.4% | −61.5% | +6.7% |
| IQV IQVIA Holdings Inc. | 8 of 12 | +14.7% | −15.1% | +12.9% | −27.4% | +57.5% | +16.0% | +33.0% | +18.7% | +28.7% | +10.8% | +16.6% | +27.0% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| MRK Merck & Co., Inc. | 11 of 29 | +9.8% | −6.3% | +1.0% | +49.4% | +1.8% | −7.2% | +22.3% | +40.0% | −1.5% | +15.0% | −3.9% | +16.9% | +26.9% | +13.1% | +9.6% | +2.9% | +26.7% | −45.3% | +37.3% | +42.8% | +4.0% | −27.7% | −11.2% | −1.2% | −36.0% | +41.8% | −7.7% | +41.6% | +35.7% |
| JNJ Johnson & Johnson | 14 of 29 | +47.5% | −4.8% | −8.6% | +6.0% | +11.4% | +10.8% | +16.2% | −5.1% | +24.4% | +15.3% | +1.2% | +17.3% | +34.6% | +10.8% | +9.9% | −0.6% | +11.3% | −7.7% | +3.6% | +12.4% | −3.4% | +25.2% | −2.0% | −7.9% | +14.0% | +14.2% | +12.5% | +29.0% | +34.3% |
| VTRS Viatris Inc. | 11 of 29 | +5.0% | +19.7% | +2.0% | −14.3% | −26.2% | −6.8% | −26.6% | −35.2% | +10.9% | −29.4% | −4.1% | +29.9% | +58.1% | +27.9% | +1.6% | +14.6% | +86.4% | −29.7% | −29.1% | +1.1% | +14.2% | −29.6% | +63.5% | −6.4% | +49.9% | +0.7% | −19.5% | +51.3% | +27.1% |
| XBI State Street SPDR S&P Biotech ETF | 11 of 19 | +35.9% | +1.0% | +7.6% | −25.9% | −20.4% | +48.3% | +32.6% | −15.3% | +43.8% | −15.4% | +13.6% | +45.0% | +48.4% | +32.7% | +5.2% | +17.6% | +0.4% | −8.5% | +29.1% | — | — | — | — | — | — | — | — | — | — |
| AZN AstraZeneca PLC | 17 of 29 | +38.0% | −1.2% | +0.8% | +20.4% | +17.9% | +2.9% | +37.4% | +13.9% | +35.3% | −16.7% | +0.1% | +24.6% | +32.0% | +8.6% | +6.0% | +3.5% | +20.4% | +0.3% | −17.1% | +12.7% | +36.9% | −22.0% | +38.2% | −23.2% | −7.9% | +28.7% | −5.3% | +27.0% | +31.8% |
| BIIB Biogen Inc. | 14 of 29 | +15.1% | −40.9% | −6.6% | +15.4% | −2.0% | −17.5% | −1.4% | −5.5% | +12.3% | −7.4% | −9.8% | +21.4% | +91.0% | +33.0% | +64.1% | +25.3% | +12.3% | −16.3% | +15.7% | +8.6% | −32.0% | +81.5% | +10.6% | −51.9% | +9.1% | +93.0% | +318% | +36.6% | +44.7% |
| BMY Bristol-Myers Squibb Company | 12 of 29 | +0.1% | +15.8% | −26.1% | +19.0% | +2.9% | +0.4% | +27.7% | −12.9% | +7.7% | −13.5% | +19.3% | +14.2% | +70.0% | −3.8% | +39.4% | +8.8% | +14.8% | −6.1% | +4.8% | +19.9% | −6.2% | −7.2% | +29.1% | −52.4% | −26.2% | +17.1% | −2.8% | +42.9% | +77.1% |
| PFE Pfizer Inc. | 13 of 29 | +0.6% | −2.2% | −41.3% | −10.4% | +66.7% | +3.4% | −6.7% | +25.1% | +16.1% | +4.4% | +7.3% | +5.4% | +26.5% | +20.6% | +28.8% | +0.6% | +8.1% | −16.9% | −8.2% | +15.3% | −10.6% | −22.3% | +17.7% | −22.2% | −12.5% | +43.0% | −21.5% | +68.8% | +82.0% |
| TAK Takeda Pharmaceutical Company Limited | 4 of 17 | +22.7% | −3.2% | −4.8% | +20.1% | −21.6% | −3.0% | +22.1% | −38.8% | +41.3% | −14.0% | +24.4% | −6.5% | +7.4% | +5.8% | −5.0% | +21.2% | −16.1% | — | — | — | — | — | — | — | — | — | — | — | — |
| REGN Regeneron Pharmaceuticals, Inc. | 15 of 29 | +9.0% | −18.9% | +21.7% | +14.2% | +30.7% | +28.7% | +0.5% | −0.7% | +2.4% | −32.4% | +32.3% | +49.0% | +60.9% | +209% | +68.8% | +35.8% | +31.7% | −24.0% | +20.3% | +26.2% | +72.7% | −37.4% | −20.6% | −34.3% | −20.2% | +177% | +72.8% | −13.8% | −46.9% |
| DHR Danaher Corporation | 19 of 29 | +0.4% | −0.4% | −1.2% | −19.0% | +48.6% | +45.4% | +49.5% | +11.8% | +20.0% | +73.2% | +9.3% | +11.6% | +38.3% | +19.1% | −0.1% | +25.7% | +33.0% | −35.4% | +21.3% | +30.1% | −2.7% | +25.3% | +39.7% | +9.1% | −11.7% | +41.5% | −11.0% | +72.4% | +35.2% |
| NVO Novo Nordisk A/S | 18 of 29 | −39.2% | −15.9% | +54.8% | +22.6% | +63.5% | +23.3% | +28.7% | −11.8% | +54.3% | −36.6% | +39.3% | +16.7% | +15.3% | +44.0% | +4.1% | +79.3% | +27.2% | −19.8% | +57.4% | +51.3% | +5.6% | +34.6% | +43.5% | −27.0% | +14.4% | +39.0% | −1.9% | −7.3% | +54.9% |
| GSK GSK plc | 14 of 29 | +51.3% | −5.2% | +9.8% | −16.8% | +27.1% | −17.7% | +29.2% | +13.8% | −3.0% | +2.1% | −0.3% | −15.7% | +28.9% | +0.6% | +22.7% | −2.1% | +19.2% | −22.2% | −0.8% | +7.9% | +9.9% | +5.6% | +28.8% | −21.6% | −9.7% | +4.1% | −17.9% | +48.2% | +55.8% |
| SNY Sanofi | 9 of 23 | +4.9% | +1.1% | +6.5% | +0.5% | +7.0% | +0.4% | +20.5% | +6.0% | +9.9% | −1.2% | −3.4% | −11.9% | +17.1% | +36.0% | +18.8% | −13.4% | +28.7% | −26.5% | +1.0% | +7.2% | +11.6% | +8.2% | +26.2% | — | — | — | — | — | — |
Risk and diversification
How NVS has fallen, how it held up in crashes beside the S&P 500 and its popular alternatives, and what moves independently of it.
What were NVS's worst declines?
A drawdown is the decline from a peak to the lowest point before a new high. This section presents NVS's five deepest drawdowns since it began trading in 1995, alongside the S&P 500's return over the same dates, and how long each took to recover. Together, these figures show how much an investor could have lost and how long it took to get back to even.
- Not every decline was the market's doing: NVS fell 41.8% from January 1999 to March 2000, while the S&P 500 rose 10.5%.
- The slowest recovery came after NVS fell 41.8% from January 1999 to March 2000; it did not regain that peak until December 2003, four years later.
- In three of NVS's five worst declines, the S&P 500 held up better over the same dates.
Green means NVS fell less than the S&P 500 over the same dates. Based on daily closing prices with dividends reinvested.
| During | NVS fell | S&P 500, same dates | Peak | Low | Time to the low | Back at the peak | Time to recover |
|---|---|---|---|---|---|---|---|
| Dot-com bust | −41.8% | +10.5% | Jan 1999 | Mar 2000 | 14 months | Dec 2003 | 3.8 years |
| 2008 financial crisis | −41.7% | −43.1% | Aug 2008 | Mar 2009 | 7 months | Sep 2010 | 18 months |
| 2015 China and oil sell-off | −33.7% | +8.8% | Jul 2015 | Dec 2016 | 17 months | Mar 2019 | 2.3 years |
| Covid crash | −26.8% | −33.5% | Feb 2020 | Mar 2020 | 1 month | Jan 2021 | 10 months |
| No named crash | −21.4% | −5.6% | Mar 1998 | Oct 1998 | 7 months | Nov 1998 | 1 month |
How did NVS do in stock market crashes?
This section measures how far NVS, the S&P 500 and each alternative fell from peak to trough during every major market crash since 2000. A smaller decline means an investment held up better, and comparing results across crashes shows whether that resilience was consistent or a one-off.
- NVS fell less than the S&P 500 in seven of the ten crashes it has traded through. The clearest case was the dot-com bust, when NVS fell 25.7% and the S&P 500 fell 47.5%.
- Among its popular alternatives, AMGN held up best, falling less than NVS in six of the ten crashes they both traded through.
Newest crash first. Each figure is the fund's deepest fall within the crash window; green means a smaller fall than NVS.
| Investment | Held up better | 2023 regional bank crisisMar 2023 | 2022 bear marketJan 2022 | Covid crashFeb 2020 | Late-2018 sell-offSep 2018 | February 2018 volatility shockFeb 2018 | 2015 China and oil sell-offAug 2015 | 2011 euro debt crisisJul 2011 | 2010 flash crashMay 2010 | 2008 financial crisisOct 2007 | Dot-com bustMar 2000 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NVS This pageNovartis AG | — | −1.1% | −20.4% | −25.5% | −9.9% | −6.6% | −30.1% | −14.5% | −2.6% | −41.7% | −25.7% |
| SPY S&P 500State Street SPDR S&P 500 ETF | 2 of 10 | −3.4% | −24.5% | −33.7% | −19.3% | −6.5% | −12.8% | −17.9% | −1.5% | −55.2% | −47.5% |
| LLY Eli Lilly and Company | 5 of 10 | −0.6% | −11.7% | −16.9% | −10.2% | −8.6% | −19.6% | −10.9% | 0.0% | −50.0% | −54.3% |
| ABBV AbbVie Inc. | 1 of 6 | −1.5% | −21.9% | −32.1% | −18.1% | −5.8% | −29.8% | — | — | — | — |
| MCK McKesson Corporation | 1 of 10 | −0.9% | −10.5% | −32.1% | −20.7% | −6.5% | −30.8% | −14.2% | −3.5% | −57.7% | −39.4% |
| AMGN Amgen Inc. | 6 of 10 | −1.2% | −11.9% | −18.3% | −14.3% | −7.4% | −22.1% | −12.6% | −0.5% | −31.3% | −60.2% |
| GILD Gilead Sciences, Inc. | 5 of 10 | −1.6% | −20.0% | −13.7% | −22.7% | −5.5% | −28.7% | −18.2% | −2.1% | −34.3% | −53.6% |
| TEVA Teva Pharmaceutical Industries Limited | 2 of 10 | −7.4% | −34.0% | −50.3% | −40.1% | −10.7% | −21.8% | −25.8% | −2.4% | −23.5% | −34.7% |
| TMO Thermo Fisher Scientific Inc. | 3 of 10 | −2.4% | −19.8% | −24.8% | −17.2% | −8.7% | −14.7% | −24.4% | −3.6% | −53.9% | −41.8% |
| IQV IQVIA Holdings Inc. | 2 of 6 | −6.8% | −35.9% | −48.9% | −19.2% | −5.3% | −28.7% | — | — | — | — |
| MRK Merck & Co., Inc. | 3 of 10 | −2.4% | −10.8% | −19.3% | −9.7% | −6.6% | −18.2% | −17.4% | −2.3% | −63.3% | −57.5% |
| JNJ Johnson & Johnson | 5 of 10 | −1.1% | −12.7% | −25.4% | −16.9% | −8.2% | −9.0% | −9.8% | −0.1% | −34.4% | −35.9% |
| VTRS Viatris Inc. | 1 of 10 | −6.9% | −43.3% | −37.3% | −32.8% | −6.8% | −31.9% | −32.4% | −0.1% | −64.4% | −47.3% |
| XBI State Street SPDR S&P Biotech ETF | 2 of 9 | −6.9% | −43.6% | −32.9% | −32.5% | −5.5% | −42.6% | −26.7% | −4.1% | −37.5% | — |
| AZN AstraZeneca PLC | 5 of 10 | −0.5% | −25.7% | −22.6% | −11.4% | −6.4% | −18.0% | −16.4% | −1.1% | −37.4% | −43.5% |
| BIIB Biogen Inc. | 3 of 10 | −2.5% | −22.4% | −21.2% | −21.7% | −9.3% | −24.6% | −19.4% | −0.6% | −52.7% | −59.8% |
| BMY Bristol-Myers Squibb Company | 6 of 10 | −2.3% | −16.0% | −29.4% | −22.9% | −4.1% | −16.3% | −10.5% | 0.0% | −39.2% | −69.5% |
| PFE Pfizer Inc. | 3 of 10 | −1.8% | −24.6% | −21.8% | −12.3% | −8.1% | −18.2% | −16.1% | −1.8% | −49.8% | −46.0% |
| TAK Takeda Pharmaceutical Company Limited | 3 of 8 | −0.6% | −14.8% | −31.5% | −27.9% | −6.5% | −17.0% | −5.6% | −3.7% | — | — |
| REGN Regeneron Pharmaceuticals, Inc. | 2 of 10 | −0.2% | −25.8% | −12.7% | −17.3% | −7.3% | −37.7% | −23.2% | −7.2% | −49.9% | −71.6% |
| DHR Danaher Corporation | 2 of 10 | −3.2% | −22.8% | −25.9% | −13.4% | −9.8% | −14.0% | −21.8% | −0.6% | −45.7% | −33.7% |
| NVO Novo Nordisk A/S | 5 of 10 | −1.1% | −21.4% | −23.7% | −13.8% | −3.9% | −20.8% | −23.1% | −1.7% | −40.9% | −51.0% |
| GSK GSK plc | 5 of 10 | −0.3% | −37.6% | −26.5% | −11.5% | −4.3% | −15.7% | −12.4% | −2.0% | −46.6% | −45.1% |
| SNY Sanofi | 2 of 9 | −0.5% | −33.5% | −25.2% | −9.0% | −9.8% | −30.2% | −20.7% | −2.8% | −46.6% | — |
How closely does NVS move with the S&P 500?
Upside capture measures how much of the S&P 500's gains an investment kept in the months the market rose, and downside capture how much of its losses it took in the months the market fell. An investment that captures more of the gains than the losses has compounded ahead of the market over time. This section compares NVS with its popular alternatives on both measures, and on beta (how strongly each has moved with the market), over the past 10 years.
- Over the past 10 years, NVS captured 69% of the S&P 500's gains in rising months and 64% of its losses in falling months, with a beta of 0.49. That is a defensive profile: it gave up some of the market's upside in exchange for smaller losses.
- LLY took just 6% of the S&P 500's losses, against 64% for NVS, while still keeping 101% of its gains.
- Eight of the 22 popular alternatives had a higher capture ratio (upside capture divided by downside capture) than NVS's 1.08, led by LLY, MCK and ABBV.
Monthly total returns over the past 10 years, measured against SPY. 100% capture or a beta of 1.00 means moving in line with the S&P 500. Green marks a better figure than NVS's: more upside, less downside or a higher capture ratio. Sorted by capture ratio.
| Investment | Upside capture | Downside capture | Capture ratio | Beta |
|---|---|---|---|---|
| NVS This pageNovartis AG | 69% | 64% | 1.08 | 0.49 |
| LLY Eli Lilly and Company | 101% | 6% | 15.73 | 0.37 |
| MCK McKesson Corporation | 72% | 27% | 2.71 | 0.56 |
| ABBV AbbVie Inc. | 92% | 57% | 1.62 | 0.54 |
| AZN AstraZeneca PLC | 60% | 39% | 1.52 | 0.39 |
| GILD Gilead Sciences, Inc. | 52% | 36% | 1.44 | 0.35 |
| MRK Merck & Co., Inc. | 64% | 46% | 1.39 | 0.30 |
| JNJ Johnson & Johnson | 64% | 53% | 1.20 | 0.46 |
| AMGN Amgen Inc. | 74% | 64% | 1.16 | 0.54 |
| DHR Danaher Corporation | 84% | 84% | 1.01 | 0.75 |
| TMO Thermo Fisher Scientific Inc. | 104% | 104% | 1.00 | 0.81 |
| REGN Regeneron Pharmaceuticals, Inc. | 55% | 66% | 0.84 | 0.19 |
| GSK GSK plc | 51% | 61% | 0.82 | 0.52 |
| NVO Novo Nordisk A/S | 75% | 94% | 0.80 | 0.60 |
| IQV IQVIA Holdings Inc. | 128% | 167% | 0.77 | 1.31 |
| XBI State Street SPDR S&P Biotech ETF | 93% | 122% | 0.76 | 1.01 |
| BMY Bristol-Myers Squibb Company | 55% | 75% | 0.73 | 0.41 |
| SNY Sanofi | 53% | 74% | 0.72 | 0.46 |
| PFE Pfizer Inc. | 52% | 81% | 0.65 | 0.54 |
| TAK Takeda Pharmaceutical Company Limited | 34% | 58% | 0.58 | 0.44 |
| TEVA Teva Pharmaceutical Industries Limited | 55% | 116% | 0.48 | 1.11 |
| VTRS Viatris Inc. | 74% | 179% | 0.41 | 1.14 |
| BIIB Biogen Inc. | 35% | 91% | 0.38 | 0.28 |
What diversifies NVS?
Correlation measures how closely two investments move together, on a scale from 1 (in lockstep) through 0 (unrelated) to -1 (in opposite directions). This section lists large ETFs and stocks whose returns have had a low correlation with NVS's. Because such investments tend not to fall at the same time, pairing NVS with them can reduce a portfolio's overall swings.
- Moving a fifth of the money in NVS into DXJ would have cut the portfolio's volatility by 14% over the past 5 years and raised its annual return (+16.2% for NVS alone, +18.6% for the mix).
- FIX made money in six of the eight calendar years in which NVS lost money.
- Among large ETFs, DXJ, EMLP and SMH have moved largely independently of NVS over the past 5 years, with correlations of 0.48 or lower, and each still earned a positive 5-year return.
Only ETFs with at least $1.0B in assets and stocks worth at least $10B, with a correlation below 0.5 over the past 5 years and a positive return, are included, ranked by Sharpe ratio; funds that hold the same thing are shown once. The year columns are the years in which NVS lost money. The last two columns show a portfolio that is 80% NVS and 20% the other investment, rebalanced monthly.
ETFs
| Investment | Correlation | 5Y return | Sharpe | 2024 | 2021 | 2016 | 2015 | 2008 | 2007 | 2001 | 1999 | 80/20 mix volatility | 80/20 mix annual return |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NVS Novartis AG (this page) | 1.00 | +121% | 0.87 | −0.5% | −5.0% | −11.8% | −4.3% | −5.4% | −3.4% | −17.2% | −24.1% | 19.1% | +16.2% |
| DXJ InternationalWisdomTree Japan Hedged Equity Fund | 0.35 | +225% | 1.34 | +29.8% | +18.0% | +1.1% | +7.7% | −20.8% | −7.4% | — | — | 16.4% | +18.6% |
| EMLP Broad MarketFirst Trust North American Energy Infrastructure Fund | 0.48 | +101% | 1.04 | +33.4% | +23.1% | +29.8% | −25.3% | — | — | — | — | 16.9% | +16.3% |
| SMH TechnologyVanEck Semiconductor ETF | 0.13 | +323% | 0.97 | +39.1% | +42.1% | +35.6% | −0.3% | −44.7% | +6.0% | −14.6% | — | 17.6% | +21.4% |
| GLD CommoditiesSPDR Gold Shares | 0.42 | +126% | 0.96 | +26.7% | −4.2% | +8.0% | −10.7% | +4.9% | +30.4% | — | — | 17.0% | +16.9% |
| SPMO Broad MarketInvesco S&P 500 Momentum ETF | 0.25 | +136% | 0.93 | +45.8% | +22.7% | +7.4% | — | — | — | — | — | 16.8% | +17.7% |
| XLE EnergyState Street Energy Select Sector SPDR ETF | 0.32 | +177% | 0.93 | +5.6% | +53.3% | +28.0% | −21.5% | −39.0% | +36.8% | −18.2% | +18.1% | 17.7% | +18.1% |
| FDVV Dividend & IncomeFidelity High Dividend ETF | 0.49 | +85.9% | 0.92 | +21.8% | +29.3% | — | — | — | — | — | — | 17.0% | +16.0% |
| VLUE Broad MarketiShares MSCI USA Value Factor ETF | 0.39 | +109% | 0.90 | +7.2% | +28.9% | +15.3% | −4.1% | — | — | — | — | 17.3% | +16.8% |
Stocks
| Investment | Correlation | 5Y return | Sharpe | 2024 | 2021 | 2016 | 2015 | 2008 | 2007 | 2001 | 1999 | 80/20 mix volatility | 80/20 mix annual return |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NVS Novartis AG (this page) | 1.00 | +121% | 0.87 | −0.5% | −5.0% | −11.8% | −4.3% | −5.4% | −3.4% | −17.2% | −24.1% | 19.1% | +16.2% |
| CAH Medical - DistributionCardinal Health, Inc. | 0.34 | +479% | 1.55 | +19.0% | −0.4% | −17.5% | +12.6% | −39.6% | −9.8% | −2.5% | −36.8% | 17.8% | +20.8% |
| CLS Hardware, Equipment & PartsCelestica Inc. | -0.13 | +3,143% | 1.47 | +215% | +37.9% | +7.4% | −6.0% | −20.5% | −25.7% | −25.6% | +350% | 18.1% | +34.8% |
| FIX Engineering & ConstructionComfort Systems USA, Inc. | 0.03 | +1,636% | 1.46 | +107% | +89.0% | +18.3% | +67.7% | −15.2% | +2.1% | +73.7% | −58.7% | 18.0% | +30.2% |
| MCK Medical - DistributionMcKesson Corporation | 0.29 | +413% | 1.44 | +23.7% | +44.2% | −28.3% | −4.5% | −40.4% | +29.7% | +4.9% | −71.3% | 17.5% | +20.3% |
| MPC Oil & Gas Refining & MarketingMarathon Petroleum Corporation | 0.16 | +690% | 1.41 | −4.0% | +61.0% | +0.7% | +17.4% | — | — | — | — | 17.5% | +23.1% |
Common questions
What was NVS's worst drawdown?
NVS's deepest decline since it began trading in 1995 was 41.8%, from January 1999 to March 2000. It took about four years from the low to climb back to its old high.
What were NVS's best and worst years?
Over 29 full calendar years, NVS's best year was 1997, when it returned 52.9%. Its worst was 1999, with a return of -24.1%.
Is there a better investment than NVS?
Among NVS's popular alternatives, LLY, MCK and ABBV were ahead of NVS in most short and long periods. Looking beyond its popular alternatives, CAH (health care distribution) and COR (health care distribution) were ahead of NVS in most short and long periods.
Is NVS more volatile than the S&P 500?
Yes. NVS's volatility over the past 5 years was 20.7%, 1.2 times the S&P 500's 17.1%. Volatility measures how widely returns swing around their average: in roughly two years out of three, NVS's return lands within 20.7% of its average, either way. The higher it is, the rougher the ride and the harder it is to hold through a slump.
What is NVS's Sharpe ratio?
NVS's Sharpe ratio over the past 5 years was 0.87, against 0.79 for the S&P 500, so NVS earned more for each unit of risk than an index fund did. The Sharpe ratio is the return earned above cash for each unit of volatility: two investments with the same return are not equal if one got there with far bigger swings.
How correlated is NVS with the S&P 500?
Over the past 5 years, NVS's monthly returns had a correlation of 0.34 with the S&P 500. Correlation runs from 1 (moving in lockstep) through 0 (unrelated) to −1 (moving in opposite directions). They are only loosely linked, which makes it a real diversifier next to an index fund. In the table, the correlation column measures each option against NVS instead: the lower it is, the more that option would diversify a NVS holding.
What are the best alternatives to NVS?
Of the 22 popular alternatives we compared, six outperformed NVS in at least 3 of 5 short-term and 2 of 3 long-term timeframes, with dividends reinvested: LLY, ABBV and MCK.
Did NVS outperform the S&P 500?
NVS finished ahead of the S&P 500 (SPY) in ten of 29 full calendar years. In 2025, it returned +46.0%, against +17.7% for the index.
How did NVS do in stock market crashes?
NVS fell less than the S&P 500 (SPY) in seven of the ten major crashes it has traded through, and further in two. The clearest case was the dot-com bust, when NVS fell 25.7% and the S&P 500 fell 47.5%.
What diversifies NVS?
These had a low correlation with NVS over the past 5 years and still earned a positive 5-year return: among large ETFs, DXJ (correlation 0.35), EMLP (correlation 0.48) and SMH (correlation 0.13); among large stocks, CAH (correlation 0.34), CLS (correlation -0.13) and FIX (correlation 0.03). A correlation near zero means the two have moved largely independently.
How we measure
- Short-term periods are 1M, 3M, 6M, YTD, 1Y; long-term periods are 3Y, 5Y, 10Y. An investment outperformed in a period when its total return, with dividends reinvested, was higher than NVS's. Returns within 0.5 points or 3% of NVS's, whichever is larger, count as a tie.
- "Qualified" means outperforming in at least 3 of 5 short-term periods and 2 of 3 long-term periods. "All-weather" means outperforming in every long-term period and all but one short-term period.
- Popular alternatives are the funds and stocks most often compared with this one. We include only those that trade today, are not leveraged or inverse, and hold at least $200 million.
- Volatility is the annualized standard deviation of daily returns over 5 years, a measure of how much the price typically swings in a year. The Sharpe ratio is the return above cash for each unit of that volatility.
- A decline, or drawdown, runs from a peak to the lowest close before the next high. The worst decline ever uses all the price history we have; comparisons between funds use the past 10 years so that younger funds are judged on the same stretch.
- Sector overlap is the share of assets two funds hold in the same sectors. Correlation and the mixed-portfolio figures use monthly returns.
- Upside and downside capture follow Morningstar's definition: the compound monthly return in the months the S&P 500 rose (or fell), divided by the S&P 500's compound return in those months. Beta measures how strongly monthly returns have moved with the S&P 500. All three use the same window for every investment.
- Figures are computed from daily adjusted prices and update after each trading day. Past performance does not predict future results.